TAILIEUCHUNG - Báo cáo khoa học: "Radiosurgery for pituitary adenomas: evaluation of its efficacy and safety"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Radiosurgery for pituitary adenomas: evaluation of its efficacy and safety. | Castro et al. Radiation Oncology 2010 5 109 http content 5 1 109 RADIATION ONCOLOGY RESEARCH Open Access Radiosurgery for pituitary adenomas evaluation of its efficacy and safety Douglas G Castro Soraya AJ Cecílio Miguel M Canteras Abstract Object To assess the effects of radiosurgery RS on the radiological and hormonal control and its toxicity in the treatment of pituitary adenomas. Methods Retrospective analysis of 42 patients out of the first 48 consecutive patients with pituitary adenomas treated with RS between 1999 and 2008 with a 6 months minimum follow-up. RS was delivered with Gamma Knife as a primary or adjuvant treatment. There were 14 patients with non-secretory adenomas and among functioning adenomas 9 were prolactinomas 9 were adrenocorticotropic hormone-secreting and 10 were growth hormone-secreting tumors. Hormonal control was defined as hormonal response decline of more than 50 from the pre-RS levels and hormonal normalization. Radiological control was defined as stasis or shrinkage of the tumor. Hypopituitarism and visual deficit were the morbidity outcomes. Hypopituitarism was defined as the initiation of any hormone replacement therapy and visual deficit as loss of visual acuity or visual field after RS. Results The median follow-up was 42 months 6-109 months . The median dose was 12 5 Gy 9 - 15 Gy and 20 Gy 12 - 28 Gy for non-secretory and secretory adenomas respectively. Tumor growth was controlled in 98 41 in 42 of the cases and tumor shrinkage ocurred in 10 4 in 42 of the cases. The 3-year actuarial rate of hormonal control and normalization were 62 4 and 37 6 respectively and the 5-year actuarial rate were 81 2 and 55 4 respectively. The median latency period for hormonal control and normalization was respectively 15 and 18 months. On univariate analysis there were no relationships between median dose or tumoral volume and hormonal control or normalization. There were no patients with visual deficit and 1 patient had .

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