TAILIEUCHUNG - Application of serum proteomics to the Women’s Health Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findings

An intensive weight loss program in Slovenia including behavioral, psychological, cognitive and physical ele- ments has shown promising long-term results on 48 sub- jects [21]. Median weight loss of completers when they left the program was kg. At least 5 years later, 13 of them still maintained the reduced weight. It is important to note that only participants who had successfully completed at least 4 months of treatment were included in the analysis. This criteria probably al- lowed selection of individuals already more successful or motivated than the ones who had quit the program after less than 4 months. In comparison, subjects were includ- ed in the present study after being. | Research Application of serum proteomics to the Women s Health Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findings Hiroyuki Katayama 4 Sophie Paczesny Ross Prentice Aaron Aragaki Vitor M Faca Sharon J Pitteri Qing Zhang Hong Wang Melissa Silva Jacob Kennedy Jacques Rossouw Rebecca Jackson Judith Hsia Rowan Chlebowski JoAnn Manson and Samir Hanash Addresses Molecular Diagnostics Program Fred Hutchinson Cancer Research Center Fairview Avenue North Seattle WA 98109 USA. Laboratory of Core Technology Eisai Co. Ltd 5-1-3 Tokodai Tsukuba Ibaraki 300-2635 Japan. Department of Pediatrics University of Michigan Cancer Center 1500 E. Medical Center Drive Ann Arbor MI 48109 USA. Public Health Sciences Division Fred Hutchinson Cancer Research Center Fairview Avenue North Seattle WA 98109 USA. Women s Health Initiative Branch National Heart Lung and Blood Institute Rockledge Dr. Bethesda MD 20892 USA. Division of Endocrinology Ohio State University Dodd Dr. Columbus OH 43210 USA. AstraZeneca LP Concord Pike Wilmington DE 29850 USA. Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center W. Carson Street Torrance CA 90502 USA. Brigham and Women s Hospital Harvard Medical School Boylston Street Boston MA 02215 USA. These authors contributed equally to this work. Correspondence Samir Hanash. Email shanash@ Published 29 April 2009 Genome Medicine 2009 1 47 doi gm47 The electronic version of this article is the complete one and can be found online at http content 1 4 47 Received 15 January 2009 Revised 29 March 2009 Accepted 29 April 2009 2009 Katayama et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The .

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