TAILIEUCHUNG - Risk of second primary cancer in men with breast cancer

In contrast, only three percent of women who had a negative HPV DNA test for 13 high risk types developed CIN3+ within the timeframe of the study, indicating that frequent screening of these women may be unnecessary. The researchers found that although infection with some types, such as HPV 53, 56, 59, and 68, were prone to persist for 2 years, they did not lead to lesions during the entire follow-up period. A study in Italy18 investigated the efficacy of HPV DNA testing for CIN and cervical cancers and supported the use of stand-alone HPV DNA testing as. | Available online http content 9 1 R10 Research article Risk of second primary cancer in men with breast cancer Sacha Satram-Hoang Argyrios Ziogas and Hoda Anton-Culver Open Access Epidemiology Division School of Medicine University of California Irvine CA 92697 USA Corresponding author Hoda Anton-Culver hantoncu@ Received 22 Sep 2006 Revisions requested 13 Nov 2006 Revisions received 21 Nov 2006 Accepted 25 Jan 2007 Published 25 Jan 2007 Breast Cancer Research 2007 9 R10 doi bcr1643 This article is online at http content 9 1 R10 2007 Satram-Hoang et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction A retrospective registry-based cohort study was conducted to examine the risk of second primary cancer following the occurrence of breast cancer in males. Methods Data obtained from the California Cancer Registry in the period 1988 to 2003 included 1 926 men aged 85 years and younger diagnosed with a first primary breast cancer. Person-year analysis was applied to determine the risk of second primary cancers after the occurrence of a first primary breast cancer. The effects of age race and time since the first breast cancer diagnosis were assessed. Results Of the 1 926 male breast cancer cases 221 developed a second primary cancer. Men with first incidence of breast cancer have a significantly higher risk of second cancer standardized incidence ratio SIR 95 confidence interval CI . The risk of a second site-specific cancer is elevated for breast cancer SIR 95 CI cutaneous melanoma SIR 95 CI and stomach cancer SIR 95 CI . There is a general tendency towards higher risks of

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