TAILIEUCHUNG - Báo cáo khoa học: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced chemokine release in both TRAIL-resistant and TRAIL-sensitive cells via nuclear factor kappa B

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a variety of tumour cells, but not in most normal cells, and has attracted considerable attention for its potential use in cancer therapy. Recently, increasing evidence has shown that TRAIL is involved in inflam-mation, although much of this evidence is controversial. | ỊFEBS Journal Tumour necrosis factor-related apoptosis-inducing ligand TRAIL -induced chemokine release in both TRAIL-resistant and TRAIL-sensitive cells via nuclear factor kappa B Wanhu Tang Weimin Wang Yaxi Zhang Shilian Liu Yanxin Liu and Dexian Zheng NationalLaboratory of MedicalMolecular Biology Institute of Basic MedicalSciences Chinese Academy of MedicalSciences and Peking Union MedicalCollege China Keywords apoptosis cancer therapy chemokine NF-kB trail Correspondence D. Zheng and Y. Liu Institute of Basic MedicalSciences Chinese Academy of MedicalSciences and Peking Union Medical College 5 Dong Dan San Tiao Beijing 100005 China Fax 86 10 65105102 Tel 86 10 65296409 E-mail zhengdx@ liuyx2000@ Received 10 September 2008 revised 12 November 2008 accepted 19 November 2008 doi Tumour necrosis factor-related apoptosis-inducing ligand TRAIL induces apoptosis in a variety of tumour cells but not in most normal cells and has attracted considerable attention for its potential use in cancer therapy. Recently increasing evidence has shown that TRAIL is involved in inflammation although much of this evidence is controversial. In this article it is shown that TRAIL induces CXCL2 CCL4 and CCL20 secretion in a nuclear factor kappa B-dependent manner. The dominant negative constructs of tumour necrosis factor receptor-associated death domain protein TRADD and tumour necrosis factor receptor-associated factor 2 are unable to block TRAIL-induced chemokine up-regulation and the dominant negative construct of TRADD may even enhance TRAIL-triggered signals. Using small interfering RNA receptor interacting protein has been demonstrated to be essential for TRAIL-induced chemokine release. Furthermore it has been demonstrated that p38 mitogen-activated protein kinase is involved in TRAIL-induced chemokine release without any effects on nuclear factor kappa B activation suggesting that some unknown transcription factors may be .

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