TAILIEUCHUNG - Cellular Networks Positioning Performance Analysis Reliability Part 14

Tham khảo tài liệu 'cellular networks positioning performance analysis reliability part 14', kỹ thuật - công nghệ, cơ khí - chế tạo máy phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Metabolic Networking through Enzymatic Sensing Signaling and Response to Homeostatic Fluctuations 379 enables their interaction with the enzyme as shown. For instance the depicted enzyme may catalyze the phosphorylation of glucose whereas the breakdown products shown in the complexes 2 and 3 of may correspond to glyceraldehyde-3-phosphate and 3-phosphoglycerate arising on the later stages of the pathway. On the other hand such breakdown products may interconnect different pathways within a network. For instance 2-oxoglutarate dehydrogenase which oxidatively decarboxylates 2-oxoglutarate to CO2 and succinyl-CoA may bind malonate 3C and glyoxylic acid 2C Bunik Pavlova 2006 which may be regarded as the breakdown derivatives of the 2-oxoglutarate 5C molecule. 1 2 3 Fig. 1. Binding of a substrate black in 1 and structurally relevant intermediates black in 2 and 3 to an enzyme grey . Certain flexibility of an enzyme structure realized as a conformational change of its binding site in the presence of a ligand hand-glove model is schematically presented as a slight structural difference between the enzyme binding site in the free state and when ligand is bound. Competition for the enzyme binding site between the substrate and intermediate will affect enzymatic transformation of substrate. This change in the enzyme catalytic properties enables the network coordination dependent on the relative concentrations of the intermediates. In the simplest case of the competitive inhibitor the binding of a nontransformed structural analog of the enzyme substrate blocks the correct binding of the substrate and hence blocks catalysis . However taking into account multiple binding points relatively extended structures of both the enzyme ligands and binding sites and different enzyme-substrate complexes along the reaction pathway multiple binding modes of ligands are possible and those may have different consequences for catalysis. A good example of this type of the .

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