TAILIEUCHUNG - báo cáo khoa học: "The inheritance of halothane susceptibility"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The inheritance of halothane susceptibil | Génét. Sél. Evol. 1983 15 l 65-82 The inheritance of halothane susceptibility in pigs . CARDEN . HILL and . WEBB . Animal Breeding Research Organisation West Mains Road Edinburgh EH9 3JQ . On leave from . Pergamino . . 31 2700 Pergamino Buenos Aires Argentina Institute of Animal Genetics University of Edinburgh West Mains Road Edinburgh EH9 3JN . Summary The mode of inheritance of the reaction to halothane anaesthesia in pigs was investigated in 40 litters by 14 sires in a Pietrain-Hampshire synthetic population and in 60 litters by 28 sires in a British Landrace experimental herd. The single-recessive mode of inheritance was tested as a hypothesis in the context of I a single-locus-two-alleles model where both the heterozygotes and one of the homozygotes react to the anaesthetic and II a two-locus model involving a susceptibility locus and a suppressor locus both assumed to have two alleles. Maximum likelihood techniques were used to fit the models to the data. The results of the single-locus analysis did not disprove the single-recessive hypothesis in Pietrain-Hampshire. The same analysis provided strong evidence to reject a strictly recessive mode of inheritance in British Landrace the parameter estimates indicated that about a quarter of the heterozgotes were positive reactors after the halothane test. Although not conclusive the two-locus analysis in Pietrain-Hampshire indicated that the addition of a suppressor locus to a single-recessive model could improve the genetic explanation of halothane testing results. The two-locus analysis also rejected the single-recessive hypothesis as the mode of inheritance of halothane susceptibility in British Landrace pigs. Key-words Halothane susceptibility inheritance pigs. Resume ưhérédité de la sensibilité à I halothane chez le pore Le mode de transmission de la reaction à 1 anesthésie à 1 halothane a été examine dans 40 portệes issues de 14 verrats dans une population sỵnthétique .

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