TAILIEUCHUNG - Chapter 113. Introduction to Infectious Diseases: Host–Pathogen Interactions (Part 2)

Host Factors in Infection For any infectious process to occur, the pathogen and the host must first encounter each other. Factors such as geography, environment, and behavior thus influence the likelihood of infection. Although the initial encounter between a susceptible host and a virulent organism frequently results in disease, some organisms can be harbored in the host for years before disease becomes clinically evident. For a complete view, individual patients must be considered in the context of the population to which they belong. Infectious diseases do not often occur in isolation; rather, they spread through a group exposed from a. | Chapter 113. Introduction to Infectious Diseases Host-Pathogen Interactions Part 2 Host Factors in Infection For any infectious process to occur the pathogen and the host must first encounter each other. Factors such as geography environment and behavior thus influence the likelihood of infection. Although the initial encounter between a susceptible host and a virulent organism frequently results in disease some organisms can be harbored in the host for years before disease becomes clinically evident. For a complete view individual patients must be considered in the context of the population to which they belong. Infectious diseases do not often occur in isolation rather they spread through a group exposed from a point source . a contaminated water supply or from one individual to another . via respiratory droplets . Thus the clinician must be alert to infections prevalent in the community as a whole. A detailed history including information on travel behavioral factors exposures to animals or potentially contaminated environments and living and occupational conditions must be elicited. For example the likelihood of infection by Plasmodium falciparum can be significantly affected by altitude climate terrain season and even time of day. Antibiotic-resistant strains of P. falciparum are localized to specific geographic regions and a seemingly minor alteration in a travel itinerary can dramatically influence the likelihood of acquiring chloroquine-resistant malaria. If such important details in the history are overlooked inappropriate treatment may result in the death of the patient. Likewise the chance of acquiring a sexually transmitted disease can be greatly affected by a relatively minor variation in sexual practices such as the method used for contraception. Knowledge of the relationship between specific risk factors and disease allows the physician to influence a patient s health even before the development of infection by modification of these risk .

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