TAILIEUCHUNG - Infectious diseases - Radiology (Volume 2): Part 2

(BQ) Continued part 1, part 2 of the document Infectious diseases - Radiology has contents: Neonatal tetanus, other infectious diarrhea, pulmonary tuberculosis, typhoid and paratyphoid fever, schistosomiasis, radiology of parasitic infections,. and other contents. Invite you to refer. | Neonatal Tetanus 16 Yinglin Guo Lili Tang and Bailu Liu Neonatal tetanus is an acute infectious disease characterized by trismus as well as systemic muscular rigidity and spasm caused by tetanospasmin which is produced after Clostridium tetani C. tetani invade the navel. Etiology C. tetani is a rod-shaped Gram-positive bacillus with a length of 2-18 pm and a width of pm. It is strictly anaerobic with surrounding flagella but no capsule. C. tetani is characterized by forming wider round-shaped spore at the top of the thallus producing a drumstick appearance microscopically. Filmlike spreading growth emerges after an incubation period of 24 h at 37 C on blood plates with accompanying p hemolysis. It performs neither carbohydrate fermentation nor proteolysis. Spores can be damaged at 100 C and can survive in the dry soil and dusts for decades. C. tetani plays a pathogenetic role primarily by producing two types of exotoxins tetanospasmin and tetanolysin. Tetanospasmin is plasmid encoding. As a neurotoxin it constitutes the major pathogenic substance to cause tetanus with high affinity to brainstem nerve cells and the anterior horn cell nucleus of spinal cords. The toxin can be absorbed by local never cells or travels along with lymph and blood flow to invade the central nerve system with strong toxicity which is just weaker than botulin. Chemically it is a heatsensitive protein that can be dissolved at 65 C for 30 min or be destructed by digestive proteinases in intestinal tract. Tetanolysin is sensitive to oxygen whose function and antigenicity resemble to streptolysin O but its pathogenesis underlying the occurrence of tetanus remains elusive. Y. Guo Department of Radiology Taiping People s Hospital Daowai District Harbin Heilongjiang China e-mail guoyinglinhmu@ L. Tang B. Liu CT Department The Second Affiliated Hospital Harbin Medical University Harbin Heilongjiang China Epidemiology C. tetani is ubiquitous in soil dusts and stool of .

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