TAILIEUCHUNG - Biomedical Engineering From Theory to Applications Part 6

Tham khảo tài liệu 'biomedical engineering from theory to applications part 6', kỹ thuật - công nghệ, cơ khí - chế tạo máy phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | 140 Biomedical Engineering - From Theory to Applications concentration which makes it a challenging fluid for microfluidic applications. In one study pre-processing the saliva via filtration through a pm membrane was found to remove 92 of total proteins and 97 of the mucins so that treated saliva could be analyzed in a microfluidic sensor Helton et al. 2008 . However sensor fouling still remained an issue. Another study used a commercially available sorbent within a microdevice as a preparatory stage for microscale capillary electrophoresis to concentrate hydroxyl radicals while removing undesirable saliva components Marchiarullo et al. 2008 . While these preprocessing stages are not compatible with reusability they may provide an avenue to preprocessing saliva for use in a reusable device. Other sample types of interest include examination of potable water for toxin and bacterial content animal fluids and cell cultures for which the strategies discussed above are applicable. Throughout the rest of this document the term analyte or target refers to the component of the sample that is to be analyzed. An assay is simply a test performed on a sample to yield information on the desired target. Chip design For a reusable device the potential for cross-contamination is a major concern. Designs should therefore minimize residence time of the sample near the walls to minimize the opportunity for adsorption. In general channels of uniform height without sharp bends steps expansions or contractions will have less opportunity to form stagnation zones that could increase sample residence time near the walls. A continuous uniform flow rate also limits the potential for fluid eddies that could bring the sample into contact with the wall. On the other hand devices with unavoidable and persistent stagnation zones could benefit from periodic disruption by pulsatile flow Corbett et al. 2010. Unless a competing design presents substantial advantages and minimal compromises in

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