TAILIEUCHUNG - Chapter 121. Intraabdominal Infections and Abscesses (Part 1)

Harrison's Internal Medicine Chapter 121. Intraabdominal Infections and Abscesses Intraabdominal Infections and Abscesses: Introduction Intraperitoneal infections generally arise because a normal anatomic barrier is disrupted. This disruption may occur when the appendix, a diverticulum, or an ulcer ruptures; when the bowel wall is weakened by ischemia, tumor, or inflammation (., in inflammatory bowel disease); or with adjacent inflammatory processes, such as pancreatitis or pelvic inflammatory disease, in which enzymes (in the former case) or organisms (in the latter) may leak into the peritoneal cavity. Whatever the inciting event, once inflammation develops and organisms usually contained within the bowel or another. | Chapter 121. Intraabdominal Infections and Abscesses Part 1 Harrison s Internal Medicine Chapter 121. Intraabdominal Infections and Abscesses Intraabdominal Infections and Abscesses Introduction Intraperitoneal infections generally arise because a normal anatomic barrier is disrupted. This disruption may occur when the appendix a diverticulum or an ulcer ruptures when the bowel wall is weakened by ischemia tumor or inflammation . in inflammatory bowel disease or with adjacent inflammatory processes such as pancreatitis or pelvic inflammatory disease in which enzymes in the former case or organisms in the latter may leak into the peritoneal cavity. Whatever the inciting event once inflammation develops and organisms usually contained within the bowel or another organ enter the normally sterile peritoneal space a predictable series of events takes place. Intraabdominal infections occur in two stages peritonitis and if the patient survives this stage and goes untreated abscess formation. The types of microorganisms predominating in each stage of infection are responsible for the pathogenesis of disease. Peritonitis Peritonitis is a life-threatening event that is often accompanied by bacteremia and sepsis syndrome Chap. 265 . The peritoneal cavity is large but is divided into compartments. The upper and lower peritoneal cavities are divided by the transverse mesocolon the greater omentum extends from the transverse mesocolon and from the lower pole of the stomach to line the lower peritoneal cavity. The pancreas duodenum and ascending and descending colon are located in the anterior retroperitoneal space the kidneys ureters and adrenals are found in the posterior retroperitoneal space. The other organs including liver stomach gallbladder spleen jejunum ileum transverse and sigmoid colon cecum and appendix are within the peritoneal cavity. The cavity is lined with a serous membrane that can serve as a conduit for fluids a property exploited in peritoneal dialysis .

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