TAILIEUCHUNG - Báo cáo khoa học: " Serum interferon-gamma and interleukins-6 and -8 during infection with Fasciola gigantica in cattle and buffaloes"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Serum interferon-gamma and interleukins-6 and -8 during infection with Fasciola gigantica in cattle and buffaloes | J. Vet. Sci. 2005 6 2 135-139 JOURNAL OF Veterinary Science Serum interferon-gamma and interleukins-6 and -8 during infection with Fasciola gigantica in cattle and buffaloes Elizabeth C. Molina School of Tropical Veterinary Science James Cook University Townsville Queensland 4811 Australia This study investigated the presence of cytokines interferon IFN -gamma interleukins IL -6 and -8 in serum of cattle and buffaloes infected with Fasciola gigantica from one to 16 weeks post-infection to determine their T cell response during infection. The concentration of these cytokines was determined by sandwich enzyme-linked immunosorbent assay ELISA . No IFN-gamma was detected in these animals while IL-6 was elevated from one to 16 weeks postinfection. Levels of IL-8 were also elevated in infected buffaloes from one to 16 weeks post-infection. A predominantly T helper Th 2 response which started early in the infection was apparently present in cattle and buffaloes in this study which was characterised by IL-6. IL-8 production could be another mechanism of immune response in buffaloes during infection with F gigantica. Key words buffaloes cattle cytokines Fasciola gigantica Introduction Fasciola gigantica is a common parasite of cattle and buffaloes in the tropics and causes significant economic losses to agricultural and livestock production 26 28 . Despite the importance of tropical fasciolosis information on the nature of the immune response induced during infection is limited. Generally helminth infections are manifested by suppression of T helper Th 1 function and induction of T cells which express cytokines characteristic of the Th2 subset 5 10 Studies with F hepatica in cattle and sheep have demonstrated that the T cell response is polarized towards a type 2 response 5 6 17 18 29 . There is no published information regarding cytokine profiles during F gigantica infection hence information on T cell response during infection is lacking. This study was undertaken to .

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