TAILIEUCHUNG - Báo cáo sinh học: " Anti-metastatic effects of viral and non-viral mediated Nk4 delivery to tumours"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Anti-metastatic effects of viral and non-viral mediated Nk4 delivery to tumours | Genetic Vaccines and Therapy BioMed Central Short paper Anti-metastatic effects of viral and non-viral mediated Nk4 delivery to tumours Alexandra Buhles Sara A Collins Jan P van Pijkeren Simon Rajendran Michelle Miles Gerald C O Sullivan Deirdre M O Hanlon and Mark Tangney Open Access Address Cork Cancer Research Centre Mercy University Hospital Leslie C Quick Junior Laboratory University College Cork Cork Ireland Email Alexandra Buhles - alexandrabuhles@ Sara A Collins - Jan P van Pijkeren - vanpijkeren@ Simon Rajendran - simonrajendran@ Michelle Miles - mmmichelle30@ Gerald C O Sullivan - geraldc@ Deirdre M O Hanlon - deirdreohanlon@ MarkTangney - Corresponding author Published 9 March 2009 Received 29 October 2008 T .r J_. A II- Accepted 9 March 2009 Genetic Vaccines and Therapy 2009 7 5 doi 186 1479-0556-7-5 This article is available from http content 7 1 5 2009 Buhles et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The most common cause of death of cancer sufferers is through the occurrence of metastases. The metastatic behaviour of tumour cells is regulated by extracellular growth factors such as hepatocyte growth factor HGF a ligand for the c-Met receptor tyrosine kinase and aberrant expression activation of the c-Met receptor is closely associated with metastatic progression. Nk4 also known as Interleukin IL 32b is a competitive antagonist of the HGF c-Met system and inhibits c-Met signalling and tumour metastasis. Nk4 has an additional anti-angiogenic activity independent of its HGF-antagonist function. Angiogenesis-inhibitory as well as cancer-specific apoptosis .

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