TAILIEUCHUNG - Báo cáo sinh học: "Distant metastasis: not out of reach any mor"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Distant metastasis: not out of reach any more. | Journal of Biology BioMed Central Minireview Distant metastasis not out of reach any more Francois Bertucci t and Daniel Birnbaum Address Centre de Recherche en Cancérologie de Marseille laboratoire d Oncologie Moléculaire UMR891 Inserm Institut Paoli-Calmettes 13009 Marseille France. tDépartement d Oncologie Médicale Institut Paoli-Calmettes 13009 Marseille France. Faculté de Médecine Université de la Méditerranée Marseille France. Correspondence Daniel Birnbaum. Email Published 27 March 2009 Journal of Biology 2009 8 28 doi jbiol128 The electronic version of this article is the complete one and can be found online at http content 8 3 28 2009 BioMed Central Ltd Abstract Metastasis is the major cause of death in breast cancer patients. Gene-expression studies have shown that the likelihood of metastasis can be predicted from analysis of primary tumors. Two recent papers in BMC Medicine and BMC Cancer have established new operational expression signatures containing a limited number of genes involved in angiogenesis or cell proliferation. Breast cancer is the second leading cause of cancer-associated mortality in women in Western countries. The main event leading to death in breast cancer patients is the development of metastases - secondary locations of cancer cells in sites distant from the primary tumor. Today the number of patients with metastatic breast cancer has declined thanks largely to improvements in the systemic adjuvant treatment of early-stage disease designed to eradicate micrometastases. Nevertheless approximately 6-10 of patients have metastatic disease at the time of diagnosis and 30 of initially non-metastatic patients will eventually develop metastatic relapse. The prognosis for these patients is poor with an estimated 5-year survival of only 21 . Despite a wealth of studies metastasis is not well understood and is poorly controlled clinically. Recent data have suggested that the capacity to metastasize

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