TAILIEUCHUNG - AIR POLLUTION AND GENETIC INFLUENCES ON BONE MINERAL DENSITY AND OSTEOPOROSIS

Unlike stratospheric ozone that protects life on earth, tropospheric ozone is highly toxic and is the main pollutant of the atmosphere of industrialized countries and cities. Its precursors are emanated from industrial activities and traffic. Generated by lightning, photochemical reactions or with free radicals, it has a density of times greater than air and is maintained close to the ground. It decomposes easily, generating free radicals with oxidizing power. The main primary pollutants leading to ozone formation are nitrogen oxides, volatile organic compounds and methane. The amount of tropospheric ozone varies in different areas and in time, its assessment is very difficult, monitoring of the precursor being necessary. Atmospheric pollution, by blocking some. | Cevei M. Stoicănescu D. - Air Pollution And Genetic Influences On Bone Mineral Density And Osteoporosis AIR POLLUTION AND GENETIC INFLUENCES ON BONE MINERAL DENSITY AND OSTEOPOROSIS Mariana CEVEI Dorina STOICĂNESCU University of Oradea Faculty of Medicine and Pharmacy Medical Rehabilitation Clinical Hospital Felix Spa Romania University of Medicine and Pharmacy Victor Babef Timisoara România Corresponding author Mariana Cevei Medical Rehabilitation Clinical Hospital Felix Spa 417500 Felix România tel. 0040723281865 e-mail cevei_mariana@yahoo. com Abstract Osteoporosis is a systemic skeletal disease characterized by reduced bone mineral density disrupted bone microarchitecture and alterations in the amount and variety of proteins in bones. Bone turnover is a very complex process depending on genetic and non genetic factors such as diet lifestyle or air pollution. The aim of the study was to explore genetic and environmental risk factors that contribute to osteoporosis by quantifying several factors related to bone mineral density. We assessed family history vitamin D status bone mineral density in subjects seeking advice on osteoporosis. Air pollution data were also obtained. Average concentrations of NO2 and particulate matter PM10 were calculated. Due to their synergistic effect on the organism the maximum permissible concentration calculated for all air pollutants was exceeded. In our study total body bone mineral density was inversely associated with indicators of air pollution. The prevalence of vitamin D depletion was . Genetic contribution to the etiology of osteoporosis was revealed by the positive family history for 36 affected subjects. Air pollution and vitamin D deficiency have a negative impact on bone mineral homeostasis. Keywords osteoporosis air pollution vitamin D deficiency INTRODUCTION Osteoporosis is a complex systemic skeletal disease that leads to an increased risk of fracture usually of the vertebra hip wrist and humerus. The disorder is

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