TAILIEUCHUNG - Báo cáo sinh học: "Genetic variations of the porcine PRKAG3 gene in Chinese indigenous pig breeds"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Genetic variations of the porcine PRKAG3 gene in Chinese indigenous pig breeds | Genet. Sel. Evol. 36 2004 481-486 INRA EDP Sciences 2004 DOI gse 2004012 481 Note Genetic variations of the porcine PRKAG3 gene in Chinese indigenous pig breeds Lu-Sheng Huang Jun-Wu Ma Jun Ren Neng-Shui Ding Yuan-Mei Guo Hua-Shui Ai Lin Li Li-Hua Zhou Cong-Ying Chen Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China Jiangxi Agricultural University Nanchang 330045 . China Received 31 October 2003 accepted 25 March 2004 Abstract - Four missense substitutions T30N G52S V199I and R200Q in the porcine PRKAG3 gene were considered as the likely candidate loci affecting meat quality. In this study the R200Q substitution was investigated in a sample of 62 individuals from Hampshire Chinese Min and Erhualian pigs and the genetic variations of T30N G52S and V199I substitutions were detected in 1505 individuals from 21 Chinese indigenous breeds 5 Western commercial pig breeds and the wild pig. Allele 200R was fixed in Chinese Min and Erhualian pigs. Haplotypes II-QQ and IV-QQ were not observed in the Hampshire population supporting the hypothesis that allele 200Q is tightly linked with allele 199V. Significant differences in allele frequencies of the three substitutions T30N G52S and V199I between Chinese indigenous pigs and Western commercial pigs were observed. Obvious high frequencies of the favorable alleles 30T and 52G in terms of meat quality were detected in Chinese indigenous pigs which are well known for high meat quality. However the frequency of the favorable allele 199I which was reported to have a greater effect on meat quality in comparison with 30T and 52G was very low in all of the Chinese indigenous pigs except for the Min pig. The reasons accounting for this discrepancy remain to be addressed. The presence of the three substitutions in purebred Chinese Tibetan pigs indicates that the three substitutions were ancestral mutations. A novel A G substitution at position 51 in exon 1 was identified. The

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