TAILIEUCHUNG - Báo cáo khoa học: Piezoelectric sensors based on molecular imprinted polymers for detection of low molecular mass analytes

Biomimetic recognition elements employed for the detection of analytes are commonly based on proteinaceous affibodies, immunoglobulins, single-chain and single-domain antibody fragments or aptamers. The alternative supra-molecular approach using a molecularly imprinted polymer now has proven utility in numerous applications ranging from liquid chromatogra-phy to bioassays. | ỊFEBS Journal MINIREVIEW Piezoelectric sensors based on molecular imprinted polymers for detection of low molecular mass analytes Yildiz Uludag1 2 Sergey A-Piletsky1 Anthony P. F. Turner1 and Matthew A. Cooper2 1 Cranfield Health Cranfield University Silsoe UK 2 Akubio Ltd Cambridge UK Keywords drug hapten label-free molecularly imprinted polymer QCRS quantification quartz crystal microbalance screening small molecule Correspondence M. A. Cooper Akubio Ltd 181 Cambridge Science Park Cambridge CB4 0GJ UK Fax 44 1223 225 336 Tel 44 1223 225 326 E-mail mcooper@ Received 6 July 2007 accepted 24 August 2007 doi Biomimetic recognition elements employed for the detection of analytes are commonly based on proteinaceous affibodies immunoglobulins singlechain and single-domain antibody fragments or aptamers. The alternative supra-molecular approach using a molecularly imprinted polymer now has proven utility in numerous applications ranging from liquid chromatography to bioassays. Despite inherent advantages compared with biochemi-cal biological recognition which include robustness storage endurance and lower costs there are few contributions that describe quantitative analytical applications of molecularly imprinted polymers for relevant small molecular mass compounds in real-world samples. There is however significant literature describing the use of low-power portable piezoelectric transducers to detect analytes in environmental monitoring and other application areas. Here we review the combination of molecularly imprinted polymers as recognition elements with piezoelectric biosensors for quantitative detection of small molecules. Analytes are classified by type and sample matrix presentation and various molecularly imprinted polymer synthetic fabrication strategies are also reviewed. Introduction Biosensors are analytical devices that comprise a sample-delivery mechanism with a biological recognition element and a suitable .

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