TAILIEUCHUNG - Báo cáo khoa học: Signaling pathways and preimplantation development of mammalian embryos

The mammalian preimplantation embryo is a critical and unique stage in embryonic development. This stage includes a series of crucial events: the transition from oocyte to embryo, the first cell divisions, and the establish-ment of cellular contacts. | ỊFEBS Journal REVIEW ARTICLE Signaling pathways and preimplantation development of mammalian embryos Yong Zhang1 Zhaojuan Yang1 and Ji Wu1 2 1 Schoolof Life Science and Biotechnology Shanghai Jiao Tong University China 2 Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China Shanghai Jiao Tong University China Keywords development preimplantation embryo signaling pathways signaling transduction network stage-specific expression pattern Correspondence J. Wu School of Life Science and Biotechnology Shanghai Jiao Tong University no. 800 Dongchuan Road Minhang District Shanghai 200240 China Fax 86 21 3420 4051 Tel 86 21 3420 4933 E-mail jiwu@ Received 17 April2007 revised 12 June 2007 accepted 5 July 2007 doi The mammalian preimplantation embryo is a critical and unique stage in embryonic development. This stage includes a series of crucial events the transition from oocyte to embryo the first cell divisions and the establishment of cellular contacts. These events are regulated by multiple signaltransduction pathways. In this article we describe patterns of stage-specific expression in several signal-transduction pathways and try to give a profile of the signaling transduction network in preimplantation development of mammalian embryo. An embryo is a stage in the development of plants invertebrate and vertebrate animals. Embryonic development is a key event in the organism and is under rigorous control. Preimplantation growth is one of the early embryonic development processes from a singlecell zygote to a morula to a blastocyst. Furthermore preimplantation development is critical in establishing a viable mammalian pregnancy. During this period the zygote initiates its first cell division and the first lineage cell begins to differentiate into the inner cell mass and the trophectoderm. These processes are complex and are regulated by various cell-signaling pathways. Each signal-transduction .

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