TAILIEUCHUNG - Báo cáo khoa học: Structure, location and interactions of G-quadruplexes

Four-stranded G-rich DNA structures called G-quadruplexes have been the subject of increasing interest recently. Experimental and computational techniques have been used to implicate them in important biological pro-cesses such as transcription and translation. | ễFEBS Journal MINIREVIEW Structure location and interactions of G-quadruplexes Julian L. Huppert Cavendish Laboratory University of Cambridge UK Keywords bioinformatics biophysics computational biology DNA G-quadruplex G-quartet G-tetraplex genomics RNA transcription translation Correspondence J. L. Huppert Cavendish Laboratory University of Cambridge JJ Thomson Ave Cambridge CB3 0HE UK Fax 44 1223 337000 Tel 44 1223 337256 E-mail jlh29@ Four-stranded G-rich DNA structures called G-quadruplexes have been the subject of increasing interest recently. Experimental and computational techniques have been used to implicate them in important biological processes such as transcription and translation. In this minireview I discuss how they form what structures they adopt and with what stability. I then discuss the computational approaches used to predict them on a genomic scale and how the information derived can be combined with experiments to understand their biological functions. Other minireviews in this series deal with G-quadruplex nucleic acids and human disease Wu Y Brosh RM Jr 2010 FEBS J and making sense of G-quadruplex and i-motif function in oncogene promoters Brooks TA et al. 2010 FEBS J . Received 23 February 2010 revised 23 May 2010 accepted 30 June 2010 doi Introduction Nucleic acids can form a very wide range of different structures aside from the well-known DNA double helix. This double helix is highly unusual in that the structure is largely independent of the sequence. For other structures what form they adopt and how stably is controlled by their sequences and in particular the different chemical properties of the nucleobases. It was noted in 1910 that guanine behaved differently from all other nucleobases in that it could spontaneously form a gel 1 . It then took over 50 years for the structure responsible to be discovered 2 . The core consists of square arrangements of four guanines bound together using two .

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