TAILIEUCHUNG - Chapter 068. Hematopoietic Stem Cells (Part 3)

Excess Capacity of Hematopoietic Stem Cells In the absence of disease, one never runs out of hematopoietic stem cells. Indeed, serial transplantation studies in mice suggest that sufficient stem cells are present to reconstitute several animals in succession, with each animal having normal blood cell production. The fact that allogeneic stem cell transplant recipients also never run out of blood cells in their life span, which can extend for decades, argues that even the limiting numbers of stem cells provided to them are sufficient. How stem cells respond to different conditions to increase or decrease their mature cell production remains. | Chapter 068. Hematopoietic Stem Cells Part 3 Excess Capacity of Hematopoietic Stem Cells In the absence of disease one never runs out of hematopoietic stem cells. Indeed serial transplantation studies in mice suggest that sufficient stem cells are present to reconstitute several animals in succession with each animal having normal blood cell production. The fact that allogeneic stem cell transplant recipients also never run out of blood cells in their life span which can extend for decades argues that even the limiting numbers of stem cells provided to them are sufficient. How stem cells respond to different conditions to increase or decrease their mature cell production remains poorly understood. Clearly negative feedback mechanisms affect the level of production of most of the cells leading to the normal tightly regulated blood cell counts. However many of the regulatory mechanisms that govern production of more mature progenitor cells do not apply or apply differently to stem cells. Similarly most of the molecules shown to be able to change the size of the stem cell pool have little effect on more mature blood cells. For example the growth factor erythropoietin which stimulates red blood cell production from more mature precursor cells has no effect on stem cells. Similarly granulocyte colony-stimulating factor drives the rapid proliferation of granulocyte precursors but does not affect cell cycling of stem cells. Rather it changes the location of stem cells by indirect means altering molecules such as CXCL12 that tether stem cells to their niche. Molecules shown to be important for altering the proliferation of stem cells such as the cyclin-dependent kinase inhibitor p21Cip1 have little or no effect on progenitor proliferation. Hematopoietic stem cells have governing mechanisms that are distinct from the cells they generate. Hematopoietic Stem Cell Differentiation Hematopoietic stem cells sit at the base of a branching hierarchy of cells culminating in the many

• Y học thường thức
• Hematopoietic Stem Cells
• bệnh học và điều trị
• bài giảng bệnh học
• tài liệu y khoa
• harrison interal medicine
• BMC Pediatrics
• Very small embryonic like stem cells
• Peripheral blood circulating stem cells
• Blood testing
• Premature infants
• BMC Cancer
• Hematopoietic stem cell mobilization
• Peripheral blood stem cell transplantation
• Bone marrow
• Non Hodgkin’s lymphoma
• Conditioned medium
• Umbilical cord
• Umbilical cord blood
• Mesenchymal stem cells
• Hematopoietic stem cell
• Mesenchymal stem
• Stromal cells
• Progenitor cells capable
• Homogeneous progenitor cell
• Genome Biology
• Chromatin architecture
• Chromosome 11
• Nuclear envelope protein LaminA/C
• Spermatogonial stem cells
• Radiated mice
• Gamma ray
• Chemical and biological
• The science of stem cells
• Cell differentiation
• Stem cells in the body
• Wound healing and cancer
• Cell differentiation
• The hematopoietic system
• Mesenchymal stromal cells
• Sca 1+MSCs
• Hematopoietic microenvironment
• Antigen presentation ability
• Myelodysplastic syndromes
• Hematopoietic cells
• Acute myeloid leukemia
• Hematopoietic stem cell transplantation
• Graft versus host disease
• Wharton’s jelly
• Peripheral blood stem cells
• Insufficient graft
• Autologous stem cell transplantation
• Multiple myeloma
• immunogenetics
• neuron replacement therapy
• cover hematopoietic
• stem cells
• Cell Research
• Gene Therapy
• báo cáo khoa học
• báo cáo y học
• công trình nghiên cứu về y học
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• cách trình bày báo cáo
• BMC Bioinformatics
• Functional gene set
• Dynamic network biomarker
• Relative effect analysis
• Leukemic stem cell
• AML outcome
• TRPM2 gene expression
• Abnormal myeloid progenitor cells
• BMC Anesthesiology
• Endothelial progenitor cells
• Hypoxia inducible factor 1α
• Stromal cell derived factor 1α
• báo cáo hóa học
• công trình nghiên cứu về hóa học
• tài liệu về hóa học
• Osteogenesis Imperfecta
• Laminopathies
• Progeria Syndrome
• Genetic Determinants
• Heart Rate Variation
• Cardiovascular Diseases