TAILIEUCHUNG - Báo cáo khoa học: Transient DNA ⁄ RNA-protein interactions

The great pace of biomolecular structure determination has provided a plethora of protein structures, but not as many structures of nucleic acids or of their complexes with proteins. The recognition of DNA and RNA molecules by proteins may produce large and relatively stable assemblies (such as the ribosome) or transient complexes (such as DNA clamps sliding through the DNA). | IFEBS Journal REVIEW ARTICLE Transient DNA RNA-protein interactions Francisco J. Blanco1 2 and Guillermo Montoya3 1 StructuralBiology Unit CIC bioGUNE Derio Spain 2 IKERBASQUE Basque Foundation for Science Bilbao Spain 3 StructuralBiology and Biocomputing Programme Spanish NationalCancer Research Centre CNIO Madrid Spain Keywords DNA dynamics endonuclease interaction nucleosome protein ribosome RNA structure transient Correspondence F. J. Blanco StructuralBiology Unit CIC bioGUNE Parque Tecnologico de Vizcaya 48160 Derio Spain Fax 34 9465 72502 Tel 34 9465 72521 E-mail fblanco@ Received 23 November 2010 revised 17 February 2011 accepted 11 March 2011 doi The great pace of biomolecular structure determination has provided a plethora of protein structures but not as many structures of nucleic acids or of their complexes with proteins. The recognition of DNA and RNA molecules by proteins may produce large and relatively stable assemblies such as the ribosome or transient complexes such as DNA clamps sliding through the DNA . These transient interactions are most difficult to characterize but even in stable complexes captured in crystal structures the dynamics of the whole or part of the assembly pose great technical difficulties in understanding their function. The development and refinement of powerful experimental and computational tools have made it possible to learn a great deal about the relevance of these fleeting events for numerous biological processes. We discuss here the most recent findings and the challenges that lie ahead in the quest for a better understanding of protein-nucleic acid interactions. Introduction Protein-nucleic acids interactions and structural genomics In their celebrated reports on the double helix Watson and Crick showed the strong structure-function relationship in the DNA molecule. This relationship is more intricate in the case of RNA because of its larger structural and functional .

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