TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 163

Pharmaceutical Substances Syntheses, Patents, Applications - Part 163. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Phensuximide P 1621 Phensuximide ATC N03AD02 Use antiepileptic RN 86-34-0 MF CHHnNO2 MW EINECS 201-664-6 LDS 700 mg kg M . CN 1 -methy 1-3 -phenyl-2 5-pyrrolidinedione benz- ethyl cyono- HCN ------ h2o h oldehyde ocetate phenyls uc ci ni c m et hy I - acid I amine D bis methylammonium sait I phenylsuccinic anhydride N-methyl-2-phenyl-succinamic acid CHjCOCI acetyl chloride Phensuximide Reference s US 2 643 258 Parke Davis 1953 prior. 1950 . Miller . Long . J. Am. Chem. Soc. JACSAT 73 4895 1951 75 373 1953 . Formulation s cps. g Trade Name s F Liféne Débat wfm GB Milontin Parke Davis wfm USA Milontin Parke Davis wfm Phentermine ATC A08AA01 Use appetite depressant RN 122-09-8 MF C10H15N MW EINECS 204-522-1 LD50 14 mg kg M . 105 mg kg M . CN a a-dimethylbenzeneethanamine 1622 P Phentolamine hydrochloride RN 1197-21-3 MF. C10HI5N HCl MW EINECS 214-821-9 LD5 154 mg kg M . 188 mg kg R . benz- 2-nitro- 2-methyl-2-nitro- aldehyde propane 1 -phenyl-1 -prapanol 2-amino-2-methyl- 1 -phenyl-1 -propanol I S0CI2 I ------- thionyl chloride HCI H2 Pd-CaCO3 ------------- . 2-omino-2-methyl-1 -phenylpropyl chloride hydrochloride H3C NH2 S Phentermine Reference s US 2 408 345 Merrell 1946 prior. 1942 . alternative syntheses US 2 590 079 Wyeth 1952 appl. 1947 . Formulation s cps. 30 mg tabl. 30 mg as hydrochloride Trade Name s D Netto Longcaps Neda lonamin Torbet wfm I. Lipopill Roussel- F Linyl Roussel wfm Maestretti wfm GB Duromine 3M Health Mirapront Bracco wfm Care USA Adipex-P Gate Banobese Seatrace Fastin SmithKline Beecham Oby-Cap Richwood Zantryl Ion Phentolamine ATC C04AB01 Use sympatholytic antihypertensive peripheral vasodilator RN 50-60-2 MF CI7H19N3O MW EINECS 200-053-1 LD5 35 mg kg M . 1 g kg M . CN 3- 4 5-dihydro-lH-imidazol-2-yl methyl 4-methylphenyl amino phenol monohydrochloridc RN 73-05-2 MF C17H19N3O HCI MW EINECS 200-793-5 LD50 75 mg kg R . 1250 mg kg R . monomesylate RN 65-28-1 MF Cl7HI9N3O .

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