TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 160

Pharmaceutical Substances Syntheses, Patents, Applications - Part 160. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Pentostatin P 1591 CHiCOOH H SO 1 NaCN -----3-------- sodium 3-forrnylomino-3- cyonide methyl-2-phenyl- 1. HCl 2. NaOH butane Reference s FR-M 2 594 Nordmark-Werke appl. D-prior. . Trade Name s D Modatrop Nordmark F Liprodéne Anphar wfm wfm Pentostatin Deoxycoformycin Co-vidarabine ATC L01XX08 Use adenosine deaminase inhibitor for hairy cell leucemia treatment RN 53910-25-1 MF CnHl6N4O4 MW LD50 122 mg kg M . 227 mg kg M . CN R -3- 2-deoxy-ß-D-eryt rro-pentofuranosyl -3 6 7 8-tetrahydroimidazo 4 5-i l 3 diazepin-8-ol Fermentation of streptomyces antibioticus MRRL. Reference s US 3 923 785 Parke Davis appl. . DE 2 517 596 Parke Davis appl. USA-prior. . Formulation s vial 10 mg Trade Name s D Nipent Lederle F Nipent Wyeth-Lederle GB Nipent Wyeth J Coforin Kaketsuken- Nippon Kayaku USA Nipent SuperGen Pentoxifylline ATC C04AD03 Use vasodilator RN 6493-05-6 MF C13H18N4O3 MW EINECS 229-374-5 LD5 I 108 mg kg M . 1225 mg kg M . 231 mg kg R . 1170 mg kg R . CN 3 7-dihydro-3 7-dimethyl-l- 5-oxohexyl -lH-purine- 2 6-dione 1592 P Pentoxifylline acetoacetic acid ch3 0 0 0 HBr ----- I 1 3-dibromo- ethyl ester propane Na 9 CH. 3 1 -bromo-5-hexanone I 0 ONa O N CH3 theobromine sodium salt CH3 3-ethoxycarbonyl- 2-methyl-5 6-dihydro- 4H-pyran sodium acetoacetic acid ethyl ester theobromine 1. NaOH H2O 2. H2SO4 n ---------------- Pentoxifylline Reference s DE 1 235 320 Chemische Werke Albert appl. . DS 3 422 107 Chemische Werke Albert D-prior. . US 3 737 433 Chemische Werke Albert D-prior. . Mohler W. Söder A. . ARZNAD 21 1159 1971 . Mohler W. et al. Arch. Pharm. Weinheim Ger. ARPMAS 299 448 1966 . alternative syntheses DOS 2 330 741 Chemische Werke Albert appl. . DOS 2 302 772 Chemische Werke Albert appl. . DOS 2 234 202 Chemische Werke Albert

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