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Pharmaceutical Substances Syntheses, Patents, Applications - Part 160. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Pentostatin P 1591 CHiCOOH H SO 1 NaCN -----3-------- sodium 3-forrnylomino-3- cyonide methyl-2-phenyl- 1. HCl 2. NaOH butane Reference s FR-M 2 594 Nordmark-Werke appl. 17.4.1963 D-prior. 13.11.1962 . Trade Name s D Modatrop Nordmark F Liprodéne Anphar wfm wfm Pentostatin Deoxycoformycin Co-vidarabine ATC L01XX08 Use adenosine deaminase inhibitor for hairy cell leucemia treatment RN 53910-25-1 MF CnHl6N4O4 MW 268.27 LD50 122 mg kg M i.v. 227 mg kg M p.o. CN R -3- 2-deoxy-ß-D-eryt rro-pentofuranosyl -3 6 7 8-tetrahydroimidazo 4 5-i l 3 diazepin-8-ol Fermentation of streptomyces antibioticus MRRL. Reference s US 3 923 785 Parke Davis 2.12.1975 appl. 22.4.1974 . DE 2 517 596 Parke Davis appl. 30.10.1975 USA-prior. 22.4.1974 . Formulation s vial 10 mg Trade Name s D Nipent Lederle F Nipent Wyeth-Lederle GB Nipent Wyeth J Coforin Kaketsuken- Nippon Kayaku USA Nipent SuperGen Pentoxifylline ATC C04AD03 Use vasodilator RN 6493-05-6 MF C13H18N4O3 MW 278.31 EINECS 229-374-5 LD5 I 108 mg kg M i.v. 1225 mg kg M p.o. 231 mg kg R i.v. 1170 mg kg R p.o. CN 3 7-dihydro-3 7-dimethyl-l- 5-oxohexyl -lH-purine- 2 6-dione 1592 P Pentoxifylline acetoacetic acid ch3 0 0 0 HBr ----- I 1 3-dibromo- ethyl ester propane Na 9 CH. 3 1 -bromo-5-hexanone I 0 ONa O N CH3 theobromine sodium salt CH3 3-ethoxycarbonyl- 2-methyl-5 6-dihydro- 4H-pyran sodium acetoacetic acid ethyl ester theobromine 1. NaOH H2O 2. H2SO4 n ---------------- Pentoxifylline Reference s DE 1 235 320 Chemische Werke Albert appl. 5.9.1964 . DS 3 422 107 Chemische Werke Albert 14.1.1969 D-prior. 30.8.1965 24.7.1965 10.7.1965 2.7.1965 5.9.1964 . US 3 737 433 Chemische Werke Albert 5.6.1973 D-prior. 5.9.1964 2.7.1965 10.7.1965 24.7.1965 . Mohler W. Söder A. Arzneim.-Forsch. ARZNAD 21 1159 1971 . Mohler W. et al. Arch. Pharm. Weinheim Ger. ARPMAS 299 448 1966 . alternative syntheses DOS 2 330 741 Chemische Werke Albert appl. 16.6.1973 . DOS 2 302 772 Chemische Werke Albert appl. 20.1.1973 . DOS 2 234 202 Chemische Werke Albert
