TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 151

Pharmaceutical Substances Syntheses, Patents, Applications - Part 151. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Ornipressin O 1501 Ornipressin Omipresina Orpressin ATC H01BA05 Use vasoconstrictor RN 3397-23-7 MF C45H63N13O12S2 MW EINECS 222-253-8 CN 8-L-ornithinevasopressin 7 8 9 1 2 Cys Tyr 3 4 5 6 Phe Glu Asp Cys Phe Glu Asp Cys Pro Orn Gly Z H Jos H- OH Z- OH OH -OH nh2 -nh2 nh2 -nh2 -nh2 -nh2 Pro Orn Gly Reference s FR 1 396 607 Sandoz appl. CH-prior. . Huguenin . Boissonnas . Helv. Chim. Acta HCACAV 46 1669 1963 . Bodanszky M. et al. J. Am. Chem. Soc. JACSAT 86 4452 1964 . 1502 O Orotic acid Formulation s amp. iu ml iu 5 ml Trade Name s D Por 8 Sandoz Novartis Pharma Orotic acid Acide orotique ATC A14B Use metabolic therapeutic electrolyte carrier RN 65-86-1 MF C5H4N2O4 MW EINECS 200-619-8 LD5 770 mg kg M . 2 g kg M . CN l 2 3 6-tetrahydro-2 6-dioxo-4-pyrimidinecarboxylic acid potassium sait RN 24598-73-0 MF C5H3KN2O4 MW EINECS 246-341-0 LD 0 g kg R . magnésium sait RN 34717-03-8 MF C10H6MgN4O8 MW . zinc sait RN 60388-02-5 MF C10H6N4O8Zn MW EINECS 262-207-4 choline orotate RN 24381-49-5 MF C5H14NO C5H3N2O4 MW EINECS 246-213-4 L-lysine orotate RN 28003-86-3 MF C6H14N2O2 C H4N2O4 MW EINECS 248-771-4 diketene 1 U H2br NH2 ----------k ureo U 6- chloromethyl - y-chlorooceto- rTYC1 0 0 ocetyl chloride H2O2 NoOH III ------------------- COOH Orotic oció H2N CN NaOCN O IL O h CN 2 H 1. OHC COOH NoOH 2. HCl 1. glyoxylic acid Orotic ocid ominoaceto- nitrile sodium cyonote hydantoic acid nitrile Orotic acid O 1503 0 HOOC 0 0 maleic acid monoureide trichloroacetyl chloride H O N O Orotic acid 5-bromodihydro-orotic ocid cl3C y ycl O 0 II . CHjCOOH cci3 7 y y-trichlarooceto-acetyl chloride 6- trichloromethyl -urocil IV 0 Orotic acid Reference s a DAS 1 770 117 Diamalt appl. . . DAS 2 025 247 Lonza appl. CH-prior. . b DAS 2 502 951 Diamalt appl. . US 4 113 950 Diamalt D-prior. . c CH 595 351 Lonza appl. . d US 4064 126 .

• Sinh học
• 2267 hoạt chất dược phẩm
• Sách nghiên cứu dược
• hoạt chất dược phẩm
• tổng hợp quá trình sản xuất
• sáng chế thuốc