TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 205

Pharmaceutical Substances Syntheses, Patents, Applications - Part 205. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Tiludronate disodium T 2041 H C CH-j CH3 I o 0 P 0 CH HjC n ch3 ch3 ch3 1. NoH DMF tetroisopropyl methyl enedi-phosphonote tetroisopropyl 4-chloro-phenylthio methylenedi-phosphonote 1 1. 12N oq. HCI 2. oq. NoOH HO P ONa II 0 Tiludronate disodium Reference s Ohnishi H. Nakamura T. Tsurukami H. Murakami H. Abe M. Barbier A. Bone Miner. BOM1ET 25 Suppl. 1 Abstr. 11 1994 . synthesis EP 100 718 Sanofi appl. F-prior. . monohydrate of the disodium salt EP582 515 Elf Sanofi appl. F-prior. . pharmaceutical preparations WO9 617 616 Sanofi appl. F-prior. . WO 9 641 618 Sanofi Winthrop appl. USA-prior. . pharmaceutical compositions WO9 530 421 Ciba-Geigy AG appl. GB-prior. . JP05 105 632 Meiji Seika Kaisha appl. J-prior. . EP 336 851 Sanofi appl. F-prior. . combinations with estrogenes for treatment of osteoporosis WO 9 214 474 Norwich Easton Pharmaceuticals appl. USA-prior. . WO 9 414 455 Merck Co. appl. USA-prior. . with parathyroid hormone for treatment of osteoporosis WO 9 607 418 Procter and Gamble Company appl. USA-prior. . WO 9 607 417 Procter and Gamble Company appl. USA-prior. . with growth hormone secretogogues for treatment of osteoporosis WO 9 511 029 Merck Co. appl. USA-prior. . Formulation s tabl. 200 mg 240 mg as sodium salt hemihydrate Trade Name s D Skelid Sanofi Winthrop F Skelid Sanofi Winthrop USA Skelid Sanofi 2042 T Timepidium bromide Timepidium bromide ATC A03 Use antispasmodic anticholinergic RN 35035-05-3 MF C17H22BrNOS2 MW LD50 12 mg kg M . 713 mg kg M . 7 mg kg R . 1213 mg kg R . CN 3- di-2-thienylmethylene -5-methoxy-1 1 -dimethylpiperidinium bromide HCI 5-bromo-nicotinic acid NaOH CuSO . Cu COOH 2. dimethyl sulfate CH i 3 MgBr thf 1. HCI 2. HjC Br ether .N. methyl N-meihyl-5-methoxynipecotate

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