TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 196

Pharmaceutical Substances Syntheses, Patents, Applications - Part 196. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Suprofen S 1951 Suprofen ATC M01AE07 Use anti-inflammatory analgesic 40828-46-4 MF CuHnO3S MW EINECS 255-096-9 LD50 185 mg kg M . 590 mg kg M . 226 mg kg R . mg kg R . 160 mg kg dog . CN ot-methyL4- 2 thienyIcarbonyl bcnzeneacetic acid AlCI-j COOH thiophene-Z-carboxylic odd SOCI2 thionyl chloride thiophene-2-carbonyl chloride -------------- fluorobenzene aluminum chloride 0 H C 0 o ch3 O diethyl methylmolonate tniophene 4-ethylbenzoyl tetrachloride 4-ethylphenyl 2-thienyl ketone II chloride Suprofen Reference s DOS2353 357 Janssen appl. USA-prior. . Daele . van et al. . ARZNAD 25 1495 1975 . Formulation s cps. 200 mg Trade Name s GB Suprol Cilag wfm 1 Erdöl Herdel wfm Masterfin Dompe wfm Sufenide Italfarmaco wfm Suprol Cilag wfm J Lindral Taiho Lindrax Taiho Mexaron Toyo Yozo Sulplotin Ichikawa Labs USA Suprol Ortho wfm 1952 S Surfactant TA Surfactant TA Beractant ATC R07A Use surfactant for treatment of respiratory distress syndrome RN 108778-82-1 MF unspecified MW unspecified LD 0 2000 mg kg M . 3000 mg kg M . CN beractant Production comprises a extracting mammalian lung slices with an electrolyte soln. NaCl b centrifuging the extract to collect a crude precipitation c suspending the precipitate in water adjusting specific gravity of the suspension with CaCl2 and centrifuging the suspension to separate upper emulsion layer d dialysing the emulsion and freeze-drying the dialysed soln. e treating the resultant powder with ethyl acetate collecting the insoluble material and extracting the insoluble material with an organic solvent CH3OH CHC13 and f concentrating the extract to give a solid. Reference s DE 3 021 006 Tokyo Tanabe appl. J-prior. . US 4 397 839 Tokyo Tanabe J-prior. . Formulations vial 120mg lyo. Trade Name s J Surfacten Tokyo Tanabe 1987 Suxamethonium chloride ATC M03AB01 Succinylcholine chloride Use muscle relaxant .

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