TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 110

Pharmaceutical Substances Syntheses, Patents, Applications - Part 110. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | loxaglic acid I 1091 3 6 9-trioxaundecane-dioyl chloride I COOH I 3-amino-2 4 6-trüodobenzoic ocid lotroxic ocid Reference s DAS 2 405 652 Schering AG appl. . Formulation s vial g 100 ml g 50 ml Trade Name s D Biliscopin Schering F Biliscopine Schering wfm I Chologram Schering J Biliscopin Schering loxaglic acid Acide ioxaglique ATC V08AB03 Use X-ray contrast medium RN 59017-64-0 MF C24H21I6N5O8 MW EINECS 261-560-1 LD50 g kg M . g kg R . g kg R . g kg dog . CN 3- 3- acetylmethylamino -2 4 6-triiodo-5- methylamino carbonyl benzoyl amino acetyl amino -5- 2-hydroxyethyl amino carbonyl -2 4 6-triiodobenzoic acid monosodium salt RN 67992-58-9 MF C24H20I6N5NaO8 MW EINECS 268-060-2 meglumine salt RN 59018-13-2 MF C24H21I6N5O8 C7H17NOS MW EINECS 261-561-7 0 N-phtholoyl-glycyl chloride COOH H J jT HO N rfAT NH2 0 I 2 4 6-triiodo-3- 2-hydroxyethylcorbamoyl -5-ominobenzoic ocid dimethylacetamide ------------------- cf. ioxitajamic acid synthesis COOH h2n-nh2 hydrozine COOH 2 4 6-triiodo-3- 2-hydroxy- ethylcorbamoyl -5-amino- cetomidobenzoic ocid II 1092 I loxitalamic acid 2 4 6-triiodo-3-methylcarbamoyl-5-acetylmethylomino-benzoyl chloride dimethylacetamide 2 5 3 ------------------ Referenced s US 4 014 986 Guerbet appl. GB-prior. . DE 2 523 567 Guerbet appl. GB-prior. . US 4 055 188 Guerbet GB-prior. . Formulation s amp. 393 mg ml as sodium salt Trade Name s D Hexabrix Guerbet 1979 I Hexabrix Byk Gulden F Hexabrix Guerbet 1980 J Hexabrix Eiken loxitalamic acid Acide ioxitalamique ATC V08AA05 Use X-ray contrast medium RN 28179-44-4 MF C H NA MW EINECS 248-887-5 CN 3- acetylamino -5- 2-hydroxyethyl amino carbonyl -2 4 6-triiodobenzoic acid monomethyl 5-nitroisophtholote S0CI2 thionyl chloride ethanolamine 1. Na2CO3 2. HCI . COOH II NalClj HCI Ipratropium bromide I 1093 o i JI H-jC TI ocetyl chloride DMF ------ .

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