TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 89

Pharmaceutical Substances Syntheses, Patents, Applications - Part 89. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Flugestone acetate F 881 Felunamin Hokuriku Flufacid Wakamoto Lanceat Maruko Nichisedan Nissin Paraflu Dainippon Reumajust A Horita Ristogen Kowa Yakuhin Romazal Tobishi Saal-F Towa Flugestone acetate Flurogestone acetate ATC G03 Use progcstone RN 2529-45-5 MF C23H3lFO5 MW EINECS 219-776-9 CN 11 p -17- acetyloxy -9-fluoro-11 -hydroxypregn-4-ene-3 20-dione 3 2Q-d oxo-16a 17-epoxy-4 9 11 -pregnodiene Hl CH3COOH hydrogen iodide 2- H AAp I H3COStV 2. acetic anhydride 1. Raney Ni p-toluenesulfonic acid 1. HOBr 2. No2CO3 H2O THF 3. H2F2 THF 1. hypobromous acid - n 11 3 17-dihydroxy-3 20-dioxo-9a-fluoro-4-pregnene 2. HCI CH3OH 1. p-toluenesu fonic ocid Flugestone acetate Reference s a Bergstrom . et al. J. Am. Chem. Soc. JACSAT 81 4432 1959 . b US 2 892 851 Searle prior. . US 2963 498 Searle prior. . Trade Name s USA Cronolone Searle wfm 882 F Flumazenil Flumazenil Ro-15-1788 ATC V03AB25 Use benzodiazepine antagonist treatment of benzodiazepine intoxication RN 78755-81-4 MF C15H14FN3O3 MW LDS0 4000 mg kg M . 143 mg kg M . 1300 mg kg M . 85 mg kg R . 4200 mg kg R . CN 8-fluoro-5 6-dihydro-5-methyl-6-oxo-4 7-imidazo l 5-a l 4 benzodiazepine-3-carboxylic acid ethyl ester 2-nitro-5-fluorotoluene KMnO4 potassium permanganate NO 2 COOH 2-nitro-5-fluoro- benzoic acid 1. H2 Pd-C 2. COCI2 2. phosgene 5-fluoroisatoic anhydride I HOOC 1 HI CH3 N-methyl-glycine 7-fluoro-4-methyl-3 4-dihydro-2H-1 4-benzodiazepin-2 5 1 H dione ocn- y - ch3 o koc ch3 3 ---------------------- ethyl isocyanato- acetate potassium tert-butylate Reference s EP 27 214 Hoffmann-La Roche appl. CH-prior. . US 4 316 839 Hoffmann-La Roche appl. CH-prior. . US 4 346 030 Hoffmann-La Roche appl. CH-prior. . Hunkeler W. et al. Nature London NATUAS 290 514 1981 . Formulations amp. mg 5 ml 1 mg 10ml .

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