TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 101

Pharmaceutical Substances Syntheses, Patents, Applications - Part 101. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Heparin H 1001 Uzara plus Uzara -comb. GB Quixalin Squibb wfm wfm USA Quinolor Squibb wfm Heparin ATC B01AB01 C05BA03 Use anticoagulant antithrombotic RN 9005-49-6 MF C24H38N2O35S3 x MW unspecified EINECS 232-681-7 LD5 500 mg kg M . 1950 mg kg R . CN mucopolysaccharide polysulfuric acid ester sodium salt RN 9041-08-1 MF unspecified MW unspecified LD50 2800 mg kg M . 5 g kg M . 391821 iu kg R . 779000 iu kg R . 1 g kg dog . calcium salt RN 37270-89-6 MF unspecified MW unspecified LDS0 40 g kg M . 40 g kg R . magnesium salt RN 54479-70-8 MF unspecified MW unspecified molar mass 6000-20000 according to origin From animal tissue especially bovine lung and liver e. g. autolysis of comminuted tissue parts heating with ammonium sulfate in alkaline solution filtration and acidification yield heparin as complex with protein removal of fat with alcohol and treatment with trypsine for the purpose of decomposition of proteins precipitation with alcohol and various purification methods . Reference s review Hind . Manuf. Chem. MACSAS 34 510 1963 . purification US 2 884 358 Southerm California Gland Co appl. . US 2 989 438 Uclaf appl. . DE 1 195 010 Ormonoterapia Richter appl. . US3016331 OrmonoterapiaRichter I-prior. . US4119774 AB Kabi appl. . GB 1 539 332 AB Kabi appl. S-prior. . Formulation s amp. 12500 iu 20000 iu 50000 iu 60000 iu cream eye drops and eye ointment 30000 iu 60000 iu 150000 iu as sodium salt or calcium salt syringe 5000 iu 7500 iu. ncpiuiiiuaie Trad e Named s D Calciparin Sanofi Winthrop Heparin-Injekt Immuno Heparin-Na Braun Melsungen medac Nattermann ratiopharm Heparin Novo Novo Heparin POS Ursapharm Heparin Riker Riker GB Canusal CP Pharm. Clexane Rhône-Poulenc Rorer Fragmin Pharmacia Upjohn Hepsal CP Pharm. Monoparin CP Pharm. generic and combination preparations Liquemin Roche as sodium salt Luxazone Eparina Allergan .

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