TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 84

Pharmaceutical Substances Syntheses, Patents, Applications - Part 84. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Feclobuzone 831 0 KOH 1 glycidyl n-butyl ether Reference s DOS 2 207 254 Klinge appl. . DOS 2 120 396 Klinge appl. . US 3 839 587 Klinge D-prior. . Minor et al. J. Am. Chem. Soc. JACSAT 76 2993 1954 . Formulation s cps. 100 mg Trade Name s D Valbil Procter Gamble Feclobuzone ATC M01A N02B S01B Use anti-inflammatory analgesic antipyretic RN 23111-34-4 MF C27H25C1N2O4 MW CN 4-cblorobenzoic acid 4-bulyl-3 5-dioxo-1 2-diphenyl-4-pyrazoIidinyl methyl ester HCHO n ----- phenylbutazone Cl. Cl. 4-chlorobenzoyl chloride 0 pyridine DMF 0 pyridine DMF 4-chlorobenzoyl chloride 1 2-diphenyl-4- butyl-4- hydroxy- poroform-oldehyde methyl pyrazo-lidine-3 5 dione Reference s DE 1 809 821 Lab. del Dr. Esteve appl. E-prior. . Trade Name s D Feclobuzon-Dragees Atmos wfm Felbamate W-554 ADD-03055 ATC N03AX10 Use anticonvulsant RN 25451-15-4 MF ChHi4N2O4 MW EINECS 247-001-4 LD5 i 5 g kg R p. o. 5 g kg M p. o. CN 2-Phenyl-l 3-propanediol dicarbamate 832 F Felbamate diethyl phenyl-malonate ci. phénobarbital LiAIH4 diethyl ether 2-phenyl-1 3-propanediol CH-J 1. COCI2 N toluene 2. NH3 ch3 I --------------------------------------- 1. phosgene dimethylaminabenzene 0 _ ïï HjC O NH2 toluene Felbamote ethyl carbamate 0 . H3C cho NaOMe toluene . methyl phenylacetote methyl formate methyl E -2-formyl-2-phenylacetate sodium salt II 1. H2SO4 2. NaBH4 n ------------ ----- 2. sodium borohydride O _ Il _ . Cl S NCO toluene II O Felbamate chlorosulfonyl isocyanate Referencels a US 4 982 016 Carter-Wallace USA-prior. . b US 4 868 327 Carter-Wallace usA-prior. . Ludwig . et al. J. Med. Chem. JMCMAR 12 462 1969 . c WO 9 406 737 Schering Corp. Avondale Chem. appl. USA-prior. . WO 9 427 941 Avondale Chem. appl. USA-prior. . alternative reduction of diethyl phenylmalonate to I US 5 091 595 Choi . appl. . Formulation s .

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