TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 74

Pharmaceutical Substances Syntheses, Patents, Applications - Part 74. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | F Edrophonium chloride E 731 Nutraflow Alcon -comb. Soaclens Alcon -comb. Polyclean Alcon -comb. GB Limclair Sinclair Edrophonium chloride ATC N07A Use cholinergic antidote to curare principles RN 116-38-1 MF C10HI6C1NO MW EINECS 204-138-4 LD50 8500 pg kg M . CN N-ethyl-3-hydroxy-7V 7V-dimethylbenzenaminium chloride hydroxide RN 473-37-0 MF C 0H 7NO2 MW LDm 9 mg kg M . 600 mg kg M . bromide RN 302-83-0 MF C10H16BrNO MW LDS0 9 mg kg M . 600 mg kg M . 15 mg kg dog . CH i J H3C BrCH3 Br ch3 3-dimethylamino-phenol ethyl bromide edrophonium bromide Edrophonium chloride Reference s US 2 647 924 Hoffmann-La Roche 1953 prior. 1950 . Formulation s amp. 10 mg ml vial 10 mg 10 ml Trade Name s GB Tensilon Roche wfm J Antirex Kyorin USA Enlon Ohmeda Reversol Organon Tensilon 1CN Efavirenz DMP-266 L-743726 ATC J05AG03 Use antiviral for AIDS reverse transcriptase inhibitor RN 154598-52-4 MF CI4H9C1F NO2 MW CN 4S -6-Chloro-4- cyclopropylethynyl -l 4-dihydro-4- trifluoromethyl -2F -3 l-benzoxazin-2-one R -enantiomer RN 154801-74-8 MF C14H9C1F3NO2 MW racemate RN 177530-93-7 MF C14H9C1F3NO2 MW 732 E Efavirenz q. NaOH MTBE ---------------- 4-chloroaniline pivaloyl x N- 4 chlorophenyl - chloride 2 2-dimethylproponamide I MTBE methyl tert butyl ether 1. BuLi TMEOA MTBE 2- H C O CF J n o 3. HCI HOAc I --------------------------- 2. ethyl trifluoroocetate 2. Tos-OH HjC-CN 1. p-methoxybenzy alcohol 4-chloro-2- trifluoro- ocetyl oniline hydrochloride II 1. BuLi 2. aRj3S - J-methyl-a-phenyl-1 -pyrrolidineethanol N- 4-methoxybenzyl - cyclopropyl- 4 chloro-2- trifluoro- acetylene IV acetyl an line III aS -5-chloro-a- cyclopropylethynyl -2 4-methoxyphenyl -methyl amino -a- trifluoro methyl -benzenemethanol V COCI2 k2co3 heptane THE phosgene 4S -6-chloro-4- cyclcpropylethynyl - 1 4-dihydro-1- 4 meth-oxyphenyl methyl -4 trifluoromethyl-2H- 3 1 -benzoxaztn-2-one oa preparation of cyclopropylacetylene Ce NO3 3NH4NO3 CHjCN H2O .

• Sinh học
• 2267 hoạt chất dược phẩm
• Sách nghiên cứu dược
• hoạt chất dược phẩm
• tổng hợp quá trình sản xuất
• sáng chế thuốc