TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 73

Pharmaceutical Substances Syntheses, Patents, Applications - Part 73. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Droperidol D 721 J i í HjC OH 0 -p-mentho-2 8-dien-1 -ol BF3-O C2H5 2 Dronabinol Cannabis sativa Cannabis indica Cannabis ruderalis isolation 95-120 C ----------------------------k Dronabinol __ Reference s a Handrick . et al. Tetrahedron Lett. TELEAY 1979 681. b US 4 116 979 Sheehan Inst for Research appl. prior. . US 4381 399 Aerojet appl. . c US 4 279 824 L. O. McKinney appl. . alternative methods US3734 930 US Dep. of Health appl. . Straight R. et al. Biochem. Med. BIMDA2 8 341 1973 . Ribi E. et al. Prep. Biochem. PRBCBQ 3 209 1973 . review Mechoulam R. et al. Chem. Rev. Washington D. C. CHREAY 76 75 1976 . Formulation s cps. mg 5 mg 10 mg Trade Name s USA Marinol Roxane Droperidol atc noiaxoi nosados Dehydrobenzperidol Use neuroleptic anesthetic - neuroleptanesthesia RN 548-73-2 MF C22H22FN3O2 MW EINECS 208-957-8 LD50 20 mg kg M . 30 mg kg R . 750 mg kg R . CN l- l- 4- 4-fluorophenyl -4-oxobutyl -l 2 3 6-tetrahydro-4-pyridinyl -l 3-dihydro-2 7-benzimidazol-2-one H2 Pd-C ethyl 1-benzyl-4-oxo-piperidine-3-corboxylote 140 C xylene --------------- a-phenylene-diamine Oy-N r o H 1- 1-benzyl-1 2 3 6-tetrahydro-4- pyridyl -2-benzimidazolinone 722 D Dropropizine 1- 1 6-tetro-hydro-4-pyridyl - 2- benzimidazolinone I 4-chloro-4 -fluoro-butyrophenone Na2CO3 KI Reference s GB 989 755 Janssen appl. USA-prior. . US 3 141 823 Janssen appl. . US 3 161 645 Janssen appl. . Formulation s amp. mg ml 5 mg 2 ml mg 5 ml 25 mg 10 ml tabl. 10 mg vial 5 mg 2 ml mg 5 ml 25 mg 10 ml Trade Name s D Dehydrobenzperidol Janssen-Cilag Thalamonal Janssen-Cilag -comb. F Droleptan Janssen-Cilag GB Droleptan Janssen-Cilag I Leptofen Carlo Erba - comb. Sintodian Carlo Erba J Droleptan Sankyo USA Droperidol Astra Inapsine Janssen McNeil wfm Innovar Janssen wfm Dropropizine ATC R05DB19

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