TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 65

Pharmaceutical Substances Syntheses, Patents, Applications - Part 65. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Difl ucortolone valerate D 641 .dio UCh 3 N N -dibromo-5 5- dimethylhydantoin Reference s DE 1 211 194 Schering continuation of DE 1 169 444. DEI 169 444 Schering . Kieslich K. et al. . ARZNAD 26 1462 1976 . alternative syntheses described Formulations cream ointment Trade Name s D Neribas Schering Nerisona Schering Nerisona C Schering -comb. Travocort Schering -comb. F Nerisone Schering as valerate Nerisone C Schering as valerate -comb. GB Nerisone Schering I Cortical Caber Cortifluoral Schering -comb. Dermaflogil Nuovo Cons. Sanit. Naz. -comb. Dermeval Firma Dermobios Biotekfarma -comb. Dervin Boniscontro Gazzone Dicortal Medici Flu-Cortanest Piam Impetex Roche -comb. Nerisona Schering Nerisona C Schering -comb. Temetex Roche several combination preparations Afusona Toyama Arusona Hotta Dertron Sankyo Lizatlone Kaken Lorizon Shinshin Neridalon Taiyo Nerisona Nippon Schering Sawatolone Sawai Texmeten Roche Youtolon Tatsumi 642 D Diflunisal Diflunisal ATC N02BA11 Use anti-inflammatory analgesic antipyretic RN 22494-42-4 MF C13H8F2O3 MW EINECS 245-034-9 LD5o 439 mg kg M . 392 mg kg R . CN 2 4 -difluoro-4-hydroxy l l -biphenyl -3-carboxylic acid ON _ --------------- isoamyi nitrite 4- 2 4 dif1uoro- phenyl anisole anisole aniline 4- 2 4-difluoro-phenyl phenol 1 Reference s Hannah J. et al. J. Med. Chem. JMCMAR 21 1093 1978 . DE 1 618 663 Merck Co. appl. USA-prior. . DAS 2 532 559 Merck Co. appl. USA-prior. . US 3 674 870 Merck Co. appl. USA-prior. . US 3 681 445 Merck Co. appl. USA-prior. . US 3 714 226 Merck Co. appl. prior. . alternative syntheses US 3 992 459 Merck Co. appl. . US 4 131 618 Merck Co. appl. . US 4 225 730 Merck Co. appl. prior. .

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