TAILIEUCHUNG - Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 9)

Introduction: The chemical warfare agents well known count only about 30 kinds of compounds, such as sarin, soman, tabun, VX, mustard gas, lewisite and others. When unknown toxic substances should be analyzed upon the occurrence of chemical terrorism, much more kinds of poisons and related compounds become the objects of analysis. In the Chemical Weapons Convention (CWC)a, 120 thousand compoundsb, including typical chemical warfare agents, their related compounds, precursors and decomposition products, are being listed to be controlled. In the CWC, the on-site inspection and chemical analysis to be made by the Organisation for the Prohibition of Chemical Weapons (OPCW). | 9 Analysis of chemical warfare agents and their related compounds By Shigeyuki Hanaoka Introduction The chemical warfare agents well known count only about 30 kinds of compounds such as sarin soman tabun VX mustard gas lewisite and others. When unknown toxic substances should be analyzed upon the occurrence of chemical terrorism much more kinds of poisons and related compounds become the objects of analysis. In the Chemical Weapons Convention CWC a 120 thousand compounds 1 including typical chemical warfare agents their related compounds precursors and decomposition products are being listed to be controlled. In the CWC the on-site inspection and chemical analysis to be made by the Organisation for the Prohibition of Chemical Weapons OPCW are also being defined to verify the presence of a chemical agent the latter itself or their related compounds should be analyzed rapidly and accurately. The analytical methods can be also applied to other poisons and drugs. In this chapter various analytical methods of chemical warfare agents and related compounds based on the verification defined in the CWC 1 are presented. The classification of chemical agents is shown in Table . The scheduled chemicals defined in the CWC are listed in Table the chemical agents not listed in the scheduled chemicals of CWC such as riot control agents and others are shown in Table . O Table Classification of representative chemical agents Nerve agents G agents sarin GB soman GD tabun GA V agents VX Blister agents sulfur mustard HD nitrogen mustard HN lewisite L Incapacitant 3-quinuclidinyl benzilate BZ Emetics sternutators adamsite DM diphenylchloroarsine DA diphenylcyanoarsine DC Lacrimators 2-chlorobenzylidenemalononitrile CS 2-chloroacetophenone CN Suffocating agents phosgene CG PFIB chloropicrin Blood agents cyanogen chloride CK hydrogen cyanide AC Springer-Verlag Berlin Heidelberg 2005 70 Analysis of chemical warfare agents and their related compounds O Table Scheduled

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