TAILIEUCHUNG - Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 6)

Introduction: In addition to the well known Tokyo Sarin Incident in 1995, the arsenic-adulteration incident in Wakayama and the cyanide-adulteration incident in Nagano both in 1998 seem to have triggered several ten poisoning cases, which took place in 1998–1999. An explosion incident of a chemical factory, a turnover incident of a chemical tank truck and a poisoning murder incident for insurance have also occurred recently. Such poisoning-related incidents are becoming more serious social problems also in Japan. In the arsenic-adulteration incident of Wakayama, the identification of the causative poison was delayed for some time; the serious incident itself together with. | 6 A computer system for diagnosis of causative drugs and poisons developed by the Japan Poison Information Center Tokyo by Toshiharu Yoshioka Introduction In addition to the well known Tokyo Sarin Incident in 1995 the arsenic-adulteration incident in Wakayama and the cyanide-adulteration incident in Nagano both in 1998 seem to have triggered several ten poisoning cases which took place in 1998-1999. An explosion incident of a chemical factory a turnover incident of a chemical tank truck and a poisoning murder incident for insurance have also occurred recently. Such poisoning-related incidents are becoming more serious social problems also in Japan. In the arsenic-adulteration incident of Wakayama the identification of the causative poison was delayed for some time the serious incident itself together with the criticism upon the delay made the Japanese Government reconsider the crisis-management system of Japan. Since the incident the Japan Poison Information Center has also studied how to narrow toxin candidates to a single causative one by methods other than actual analysis of toxins. As a result of such efforts the author et al. 1 have constructed a database for estimation of a causative toxin assisting system for diagnosis of a causative toxin according to clinical symptoms and a computer system for searching a toxin which had been used previously on the basis of poisoning situations. In additions by registering experts for each toxin which was targeted in the above systems information exchange between a clinical doctor treating a poisoned patient and the expert of a poison has become possible 2 . The setting up of a detailed procedure of pretreatments and of conditions for instrumental analysis is usually difficult without any estimation of a target compound. It seems very important for clinical doctors and analysts to narrow causative toxins by means other than instrumental analysis. Springer-Verlag Berlin Heidelberg 2005 46 A computer system for diagnosis

• Y học thường thức
• Drugs and Poisons in Humans
• Handbook of Practical Analysis
• tác hại của ma tuý
• chất độc hại cho con người
• phòng chống nghiện ma tuý
• computer system for diagnosis
• causative drugs
• poisons developed
• Alternative specimens
• Pretreatments of human specimens
• Detection methods
• Practical use
• the poison net developed
• Problems in toxin analysis
• emergency medicine
• Analysis of chemical warfare agents
• related compounds
• Carbon monoxide
• Hydrogen sulfide
• metabolite
• Cyanide
• Methanol and formic acid
• Ethanol
• Chloroform and dichloromethane
• Toluene
• benzene
• xylene
• styrene
• Alkyl nitrites
• Components of gasoline
• Amphetamines
• metabolites
• Cannabinoids
• Morphine and its analogues
• Cocaine and its metabolites
• Pentazocine
• Lysergic acid diethylamide
• Methylenedioxyamphetamines