TAILIEUCHUNG - Prognostic value of preoperative highsensitivity modifed Glasgow prognostic score in advanced colon cancer: A retrospective observational study

Several studies have demonstrated that the preoperative Glasgow prognostic score (GPS) and modifed GPS (mGPS) refected the prognosis in patients undergoing curative surgery for colorectal cancer. However, there are no reports on long-term prognosis prediction using high-sensitivity mGPS (HS-GPS) in colorectal cancer. Therefore, this study aimed to calculate the prognostic value of preoperative HS-GPS in patients with colon cancer. | Kasahara et al. BMC Cancer 2022 22 20 https s12885-021-09113-8 RESEARCH Open Access Prognostic value of preoperative high- sensitivity modified Glasgow prognostic score in advanced colon cancer a retrospective observational study Kenta Kasahara Masanobu Enomoto Ryutaro Udo Tomoya Tago Junichi Mazaki Tetsuo Ishizaki Tesshi Yamada Yuichi Nagakawa Kenji Katsumata and Akihiko Tsuchida Abstract Background Several studies have demonstrated that the preoperative Glasgow prognostic score GPS and modi- fied GPS mGPS reflected the prognosis in patients undergoing curative surgery for colorectal cancer. However there are no reports on long-term prognosis prediction using high-sensitivity mGPS HS-GPS in colorectal cancer. Therefore this study aimed to calculate the prognostic value of preoperative HS-GPS in patients with colon cancer. Methods A cohort of 595 patients with advanced resectable colon cancer managed at our institution was analysed retrospectively. HS-GPS GPS and mGPS were evaluated for their ability to predict prognosis based on overall survival OS and recurrence-free survival RFS . Results In the univariate analysis HS-GPS was able to predict the prognosis with significant differences in OS but was not superior in assessing RFS. In the multivariate analysis of the HS-GPS model age pT pN and HS-GPS of 2 compared to HS-GPS of 0 2 vs 0 hazard ratio HR 95 confidence interval CI P were identified as independent prognostic predictors of OS. In the multivariate analysis of the GPS model GPS 2 vs 0 HR 95 CI P and GPS 2 vs 1 HR 95 CI P and in that of the mGPS model mGPS 2 vs 0 HR 95 CI P were independent prognostic predictors of OS. In each classification GPS outperformed HS-GPS in predicting OS with a significant difference in the area under the receiver operating characteristic curve. In the multivariate analysis of the GPS model GPS 2 vs 0 HR 95 CI .

• Y khoa - Dược
• BMC Cancer
• Glasgow prognostic score
• Modified Glasgow prognostic score
• High sensitivity modified Glasgow prognostic score
• Colon cancer
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
• Breast cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study