TAILIEUCHUNG - Quantitative HBV-DNA and determination of drug-resistant mutants in patients with chronic hepatitis B virus (HBV) in Hai Duong province

After 6 months of treatment with antiretroviral drugs based on quantitative HBV-DNA. The rate of normalization of liver enzymes increased significantly. The rate of patients with quantitative HBV-DNA under the detectable level was highly significant. Patients with mutations in the RT region was highly significant () while we did not identify any mutations in the Pre-S region. | JOURNAL OF SCIENCE OF HNUE Chemical and Biological Sci. 2014 Vol. 59 No. 9 pp. 139-147 This paper is available online at http QUANTITATIVE HBV-DNA AND DETERMINATION OF DRUG- RESISTANT MUTANTS IN PATIENTS WITH CHRONIC HEPATITIS B VIRUS HBV IN HAI DUONG PROVINCE Le Thi Phuong Hai Duong Medical Technical University Abstract. The purposes of the paper are i To survey quantitative HBV-DNA in patients with HBsAg Hepatitis B surface antigen positive with antiretroviral drugs and ii To determine drug resistant mutants in the Pre-S and RT regions in patients with quantitative HBV-DNA gt 104 copies mL 6 months after treatment. 195 patients with chronic hepatitis were treated with antiretroviral drugs periodically examined and tested for biochemical indices quantitative HBV-DNA was carried out 6 months before treatment and every 3 months after treatment. After being treated for 6 months patients with quantitative HBV-DNA gt 104 copies mL would be determined to have drug resistant mutants in the RT and Pre-S regions. Group of patients with quantitative HBV-DNA levels gt 106 copies mL decreased from pre-treatment to after 3 months of treatment and after 6 months of treatment group of patients with quantitative HBV DNA positive under detection increased from 0 pre-treatment to after 3 months of treatment and after 6 months of treatment 17 195 patients with quantitative HBV-DNA decreased but possibly flared up again. These samples carried mutations in the RT and Pre-S regions. The result showed that 9 17 specimens had mutations in the region RT. There were no mutations in Pre-S. Most of the patients were in serious disease condititon before treatment. This resulted in of patients with quantitative HBV-DNA gt 106 copies mL. Keywords Quantitative HbeAg HbsAg HBV-DNA real time PCR chronic hepatitis. 1. Introduction The World Health Organization WHO estimates that over 350 and 250 million people worldwide are chronic carrier of hepatitis

TỪ KHÓA LIÊN QUAN
TAILIEUCHUNG - Chia sẻ tài liệu không giới hạn
Địa chỉ : 444 Hoang Hoa Tham, Hanoi, Viet Nam
Website : tailieuchung.com
Email : tailieuchung20@gmail.com
Tailieuchung.com là thư viện tài liệu trực tuyến, nơi chia sẽ trao đổi hàng triệu tài liệu như luận văn đồ án, sách, giáo trình, đề thi.
Chúng tôi không chịu trách nhiệm liên quan đến các vấn đề bản quyền nội dung tài liệu được thành viên tự nguyện đăng tải lên, nếu phát hiện thấy tài liệu xấu hoặc tài liệu có bản quyền xin hãy email cho chúng tôi.
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.