TAILIEUCHUNG - An efficient one pot three-component synthesis of dihydropyrano[3,2-c] chromenes using ammonium metavanadate as catalyst

We report ammonium metavanadate catalyzed one-pot synthesis of 3,4-dihydropyrano[3,2- c]chromenes, from aldehydes, active methylene compounds malononitrile and 4-hydroxycoumarin in water:ethanol(1:1) under reflux. The attractive features of this process are mild reaction conditions, short reaction times, easy isolation of products, and excellent yields. | An efficient one pot three-component synthesis of dihydropyrano 3 2-c chromenes using ammonium metavanadate as catalyst Current Chemistry Letters 5 2016 137 144 Contents lists available at GrowingScience Current Chemistry Letters homepage An efficient one pot three-component synthesis of dihydropyrano 3 2-c chromenes using ammonium metavanadate as catalyst Balasaheb V. Shitolea Nana V. Shitoleb Murlidhar S. Shingarec and Gopal K. Kakded a Vasant College Kaij-431519 India b Shri Shivaji College Parbhani-431401 India c Dr. Babasaheb Ambedkar Marathwada University Aurangabad -431 004 India d Arts Commers and Science College Dharur Kille -431519 India CHRONICLE ABSTRACT Article history We report ammonium metavanadate catalyzed one-pot synthesis of 3 4-dihydropyrano 3 2- Received January 21 2016 c chromenes from aldehydes active methylene compounds malononitrile and 4- Received in revised form hydroxycoumarin in water ethanol 1 1 under reflux. The attractive features of this process are July 10 2016 mild reaction conditions short reaction times easy isolation of products and excellent yields. Accepted 8 Septemver 2016 Available online 8 September 2016 Keywords Chromenes Multi-component reaction Ammonium metavanidate 2016 Growing Science Ltd. All rights reserved. 1. Introduction The development of multi-component reactions MCRs designed to produce elaborate biologically active compounds has become an important area of research in organic combinatorial and medicinal One-pot multi-component reaction strategies offer significant advantages over conventional linear-type syntheses by virtue of their convergence productivity facile execution and high 2-amino-tetrahydro-4H-chromene derivatives represent an important class of bioactive molecules. They are often used in cosmetics pigments3 and utilized as potential agrochemicals4. Some derivatives of chromenes constitute a core skeleton of many naturalproducts5 and .

• Hoá học
• Multi component reaction
• Catalyzed one pot synthesis
• Active methylene compounds malononitrile
• Three component synthesis
• Mild reaction condition
• Knoevenagel condensation reaction
• KOH loaded CaO
• 4H pyran derivatives
• One pot multicomponent reaction
• Solvent free condition
• Journal of Chemistry
• Guanidinium salt
• Multicomponent reaction
• Guanidine containing heterocycles
• 2 aminopyrimidine compounds
• Organic salts
• 2 hydroxy 1 4 naphthoquinone
• Crystal structure
• Hydrogen bonds
• Tạp chí khoa học
• Khoa học tự nhiên
• Mannich reaction
• Multicomponent condensation reaction
• Azacrown ether
• Natural sciences
• Aldehyde alkyne amine
• Solvent free
• Metal free
• Methods and reagents for green chemistry
• Green chemistry
• The Four Component reaction
• Other multicomponent reactions
• Dimethyl carbon
• Ultrasound accelerated arylthiomethylation
• Mannich type reactions
• Magnetic stirring and ultrasonic irradiation
• The mechanism and process
• Mannich type reactions in the synthesis
• Transition metal
• Periodic table
• Coordination compounds
• Biomedical industry
• N bromosuccinimde catalyzed
• One pot condensation
• One pot multicomponent condensation reaction
• By product N succinimide
• Environmentally benign chemical processe
• Functionalized tetrahydropyridine
• Condensed tetrahydropyridine
• Tryptamine receptor agonist
• Muscarinic receptor agonist
• 3 Amino 9 ethylcarbazole
• Arylation reactions
• Cyclization reactions
• Pyrrolo[2 3 c]carbazole
• Prido[3 2 b]carbazole
• Antitumor activity
• Mannich base
• Green synthesis
• Methylene tethered tetrahydroquinolines
• 6 aryl 3 oxo 2
• 3 dihydropyridazine 4 carbohydrazide derivatives
• Diversity oriented construction
• 6 arylpyridazinone skeleton
• Multicomponent reactions
• 1 3 4 oxadiazoles
• Trichloroacetyl isocyanate
• (N isocyanimino)triphenylphosphorane
• Aza Wittig
• Cyclic enaminones
• α β unsaturated nitriles
• Spirooxindole derivatives
• Hexahydroquinoline derivatives