TAILIEUCHUNG - Ultrasound assisted N-bromosuccinimde catalyzed one pot condensation approach for synthesis of Bis(indolyl)methanes from primary alcohols Prakash Chhattisea, b, Kalpana Handorea, Kakasaheb Mohiteb and Vasant Chabukswar a*

A simple, efficient protocol for one pot synthesis of bis(indolyl)methanes from primary alcohols is investigated with N-bromosuccinimde as a catalyst under ultrasound irradiation. | Ultrasound assisted N-bromosuccinimde catalyzed one pot condensation approach for synthesis of Bis indolyl methanes from primary alcohols Prakash Chhattisea b Kalpana Handorea Kakasaheb Mohiteb and Vasant Chabukswar a Current Chemistry Letters 5 2016 129 135 Contents lists available at GrowingScience Current Chemistry Letters homepage Ultrasound assisted N-bromosuccinimde catalyzed one pot condensation approach for synthesis of Bis indolyl methanes from primary alcohols Prakash Chhattisea b Kalpana Handorea Kakasaheb Mohiteb and Vasant Chabukswar a a Department of Chemistry Nowrosjee Wadia College SPPU Pune 19 Joag Path Pune- 411001 India b Haribhai V. Desai College SPPU Pune India - 411002 India CHRONICLE ABSTRACT Article history A simple efficient protocol for one pot synthesis of bis indolyl methanes from primary Received October 21 2015 alcohols is investigated with N-bromosuccinimde as a catalyst under ultrasound irradiation. Received in revised form Alcohols can be converted into carbonyl compounds by removal of hydrogen in presence of March 20 2016 N-bromosuccinimde as an oxidant and can react in situ with indole to give desired Accepted 2 May 2016 bis indolyl methanes. In the reported one pot multicomponent condensation reaction N- Available online 2 May 2016 bromosuccinimde promotes the oxidation of alcohol to aldehyde facilitating the subsequent condensation with indole to afford bis indolyl methanes in good to excellent yields. The Keywords inexpensiveness and easy handling are some of important feature of N-bromosuccinimde. The Indoles N-Bromosuccinmide by-product N-succinimide can be easily recovered and recycled to N-bromosuccinimide. Ultrasound Bio Indolyl Methanes 2016 Growing Science Ltd. All rights reserved. 1. Introduction Indole and its derivatives are known as an important class of heterocyclic compounds which exhibit a broad spectrum of biological activities such as antimicrobial and antifungal 1 antibacterial 2 .

• Hoá học
• N bromosuccinimde catalyzed
• One pot condensation
• One pot multicomponent condensation reaction
• By product N succinimide
• Environmentally benign chemical processe