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An efficient one pot three-component synthesis of dihydropyrano[3,2-c] chromenes using ammonium metavanadate as catalyst

We report ammonium metavanadate catalyzed one-pot synthesis of 3,4-dihydropyrano[3,2- c]chromenes, from aldehydes, active methylene compounds malononitrile and 4-hydroxycoumarin in water:ethanol(1:1) under reflux. The attractive features of this process are mild reaction conditions, short reaction times, easy isolation of products, and excellent yields. | An efficient one pot three-component synthesis of dihydropyrano 3 2-c chromenes using ammonium metavanadate as catalyst Current Chemistry Letters 5 2016 137 144 Contents lists available at GrowingScience Current Chemistry Letters homepage www.GrowingScience.com An efficient one pot three-component synthesis of dihydropyrano 3 2-c chromenes using ammonium metavanadate as catalyst Balasaheb V. Shitolea Nana V. Shitoleb Murlidhar S. Shingarec and Gopal K. Kakded a Vasant College Kaij-431519 M.S India b Shri Shivaji College Parbhani-431401 M.S India c Dr. Babasaheb Ambedkar Marathwada University Aurangabad -431 004 India d Arts Commers and Science College Dharur Kille -431519 M.S India CHRONICLE ABSTRACT Article history We report ammonium metavanadate catalyzed one-pot synthesis of 3 4-dihydropyrano 3 2- Received January 21 2016 c chromenes from aldehydes active methylene compounds malononitrile and 4- Received in revised form hydroxycoumarin in water ethanol 1 1 under reflux. The attractive features of this process are July 10 2016 mild reaction conditions short reaction times easy isolation of products and excellent yields. Accepted 8 Septemver 2016 Available online 8 September 2016 Keywords Chromenes Multi-component reaction Ammonium metavanidate 2016 Growing Science Ltd. All rights reserved. 1. Introduction The development of multi-component reactions MCRs designed to produce elaborate biologically active compounds has become an important area of research in organic combinatorial and medicinal chemistry.1 One-pot multi-component reaction strategies offer significant advantages over conventional linear-type syntheses by virtue of their convergence productivity facile execution and high yields.2 2-amino-tetrahydro-4H-chromene derivatives represent an important class of bioactive molecules. They are often used in cosmetics pigments3 and utilized as potential agrochemicals4. Some derivatives of chromenes constitute a core skeleton of many naturalproducts5 and .