TAILIEUCHUNG - Elevated HOX gene expression in acute myeloid leukemia is associated with NPM1 mutations and poor survival

Acute myeloid leukemia (AML) is a clonal disorder of hematopoietic progenitor cells and the most common malignant myeloid disorder in adults. Several gene mutations such as in NPM1 (nucleophosmin 1) are involved in the pathogenesis and progression of AML. The aim of this study was to identify genes whose expression is associated with driver mutations and survival outcome. Genotype data (somatic mutations) and gene expression data including RNA-seq, microarray, and qPCR data were used for the analysis. Multiple datasets were utilized as training sets (GSE6891, TCGA, and GSE1159). A new clinical sample cohort (Semmelweis set) was established for in vitro validation. Wilcoxon analysis was used to identify genes with expression alterations between the mutant and wild type samples. Cox regression analysis was performed to examine the association between gene expression and survival outcome. Data analysis was performed in the R statistical environment. Eighty-five genes were identified with significantly altered expression when comparing NPM1 mutant and wild type patient groups in the GSE6891 set. | Elevated HOX gene expression in acute myeloid leukemia is associated with NPM1 mutations and poor survival

• Y khoa - Dược
• Acute myeloid leukemia
• Gene expression
• Clinical samples
• HOX genes
• Poor survival
• Elevated HOX gene expression
• Chronic myeloid leukemia
• Imatinib mesylate
• Leukemia markers
• Anti leukemia drugs in myeloid leukemia
• BMC Cancer
• Acute promyelocytic leukemia
• Describe factors
• Anti bacterial prophylaxis
• Prognostic significant
• YP3A4 A 290G polymorphism
• Healthy control using PCR
• Acute myeloid leukemia patients
• Childhood acute myeloid leukemia
• Allogeneic hematopoietic stem cell transplantation
• Pediatric acute myeloid leukemia
• Overall survival
• Non Hodgkin’s lymphoma
• Related acute myeloid leukemia
• Hodgkin’s lymphoma
• Related acute myeloid leukemia following chemotherapy
• Journal of clinical Medicine
• Acute lymphoblastic leukemia
• Chronic lymphocytic leukemia
• Case rep
• Chemotherapeutic agents
• Phase I
• Myelodysplastic syndrome
• Chronic myelomonocytic leukemia
• TRPM2 gene expression
• Hematopoietic stem cells
• Abnormal myeloid progenitor cells
• Myeloid precursor cells
• Genomic alterations
• Navitoclax in combination
• Long non coding RNAs
• Overall surviva
• Childhood acute leukemia
• Acute leukemia
• Accurate cloning
• Standardize morphology
• Drug resistance
• Leukemia stem cell
• Fluorescence in situ hybridization
• Acute lympho leukemia
• Hyperleukocytic symptoms
• Clinical symptoms of leukostatsis
• AML occurring during pregnancy
• Leukemia during pregnancy
• Therapy attributable risks
• Acute myeloid leukemia; Circulating nucleophosmin
• Circulating DNA
• Real time quantitative polymerase chain reaction
• NPM mutated leukemia
• Pathology competencies
• Organ system pathology
• Myeloid neoplasia
• Myelodysplastic syndromes
• Myeloproliferative neoplasms
• Retinoic acid receptor alpha
• Alltrans retinoic acid
• Bone marrow smear
• Deep learning
• Artificial intelligence
• Acute and Chronic Myeloid Leukemia
• bệnh học và điều trị
• bài giảng bệnh học
• tài liệu học ngành y
• Harrisons Internal Medicine