TAILIEUCHUNG - Anticancer activities and mechanism of action of 2 novel metal complexes, C16H34N8 O5 Ag2 Cd and C11H16N7 O2 Ag3 Ni

The discovery of anticancer activity in cisplatin triggered the development of novel drugs containing metals such as platinum or ruthenium. Extremely diverse structural chemistry and the interaction of metal complexes with biomolecules resulted in the exploration of novel metal complexes with drug potential. | Turkish Journal of Biology Turk J Biol (2014) 38: 948-955 © TÜBİTAK doi: Research Article Anticancer activities and mechanism of action of 2 novel metal complexes, C16H34N8O5Ag2Cd and C11H16N7O2Ag3Ni 1 1 2 1, 2 Ali AYDIN , Nesrin KORKMAZ , Şaban TEKİN *, Ahmet KARADAĞ Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Gaziosmanpaşa University, Tokat, Turkey 2 Department of Chemistry, Faculty of Arts and Sciences, Gaziosmanpaşa University, Tokat, Turkey Received: Accepted: Published Online: Printed: Abstract: The discovery of anticancer activity in cisplatin triggered the development of novel drugs containing metals such as platinum or ruthenium. Extremely diverse structural chemistry and the interaction of metal complexes with biomolecules resulted in the exploration of novel metal complexes with drug potential. In the present study, the anticancer and cytotoxic activities and the mechanisms of action were investigated for C16H34N8O5Ag2Cd (AN1) and C11H16N7O2Ag3Ni (AN7), 2 newly synthesized dicyanidoargentate(I) complexes. The anticancer and cytotoxic activities of AN1 and AN7 on several cancer cell lines were tested by cell proliferation and cytotoxic activity assays, respectively. The apoptotic and replication inhibitory potentials of the compounds were investigated using terminal deoxynucleotidyl transferase dUTP nick and labeling (TUNEL) and DNA topoisomerase inhibition assays. AN1 and AN7 showed significant (P < ) anticancer activity and lower cytotoxicity against all cell lines tested. The TUNEL assay results indicated that AN1 and AN7 may inhibit cell proliferation by inducing apoptosis. The compounds showed very significant DNA topoisomerase I inhibitory activity. Based on the results, it is suggested that compounds AN1 and AN7 are potential anticancer drug candidates. Key words: Metal complexes, anticancer .

• Sinh học
• Metal complexes
• Anticancer activity
• Cytotoxic activity
• Synthesized dicyanidoargentate
• DNA topoisomerase inhibition assays
• Journal of Chemistry
• Benzimidazole metal complexes
• Transition metal complexes
• Coordination compounds
• Crystal structure
• Heavy metal
• Metal bounded biomolecules
• Heavy metal pollution
• Metal binding peptides
• Plexiglass slides
• BMC Chemistry
• Coordination chemistry
• Antimicrobial resistance
• Medicinal chemistry
• X ray crystal structure
• Hirshfeld surface analysis
• Antibacterial and antifungal
• Bidentate Schiff base ligand
• Single crystal X ray diffraction analysis
• Vibrational spectra
• Citric acid
• Citrate ion
• Phthalhydrazidylazo derivative
• Unsaturated diketone
• Keto hydrazone
• Spectral data
• Fluorescent studies
• Azo dye
• Schiff base
• X ray powder diffraction
• Electrochemical reduction reactions
• Mixed ligand
• Schiff bases
• Biological activity
• Molecular modeling
• Rare earth metal complexes
• N diethylnicotinamide
• Structural characterization
• Thermal analysis
• Mixed ligand complexes
• Calixarene Complexes
• Stoichiometric Ratio
• Water Soluble
• Spectral Methods
• DNA fragmentation
• Cancer cells
• Dulbecco’s modified Eagle medium
• Colon adenocarcinoma HT 29 cells
• Indole Schiff bases
• Binuclear complexes
• DNA cleavage
• Minimum inhibitory concentration (MIC)
• 2 sulphanilamidopyrimidine
• 2 hydroxy 3 methoxybenzaldehyde
• Fluorescent behaviour
• Arene ruthenium(II) complexes
• N heterocyclic carbene
• Transfer hydrogenation
• Naphthyl substituent
• Urease inhibitor
• Helicobacter pylori
• Canavalia ensiformis
• Metal complex
• Farmyard manure
• Humic acid
• Fulvic acid
• Metal ions
• Potentiometric titration
• Summary of Thesis Doctor of Phylosophy in Chemistry
• Inorganic chemistry
• Bioactivity of metals
• Metal complex structure
• Luminescence in metals
• Metals containing quinoline derivatives
• Metal phthalocyanine
• Electronic properties
• HOMO LUMO energy gap
• Gas detection
• Toxic volatile organic
• Metal organic complex
• X ray diffraction
• Solid state fluorescence spectra
• Ligand exchange method
• Mole ratio method
• Job’s method
• Relatively weak complexes
• Molar absorptivity
• Mannich base
• 3 4 dimethylphenol
• Microwave irradiation
• Transition metal
• N bridged dimeric complexes
• µ nitrido
• Homoleptic homometallic complexes
• π Expanded ligand
• Unique bidentate ligand
• X ray diffraction analyses
• Magnetic susceptibility
• Zinc complex
• Imine nitrogen
• UV vis spectroscopy
• Fluorescence spectroscopy