TAILIEUCHUNG - Lecture Organic chemistry - Chapter 25: Heterocycles

Lecture Organic chemistry - Chapter 25: Heterocycles. In this chapter, the following content will be discussed: Intramolecular SN2 reaction, special reaction for oxacyclopropanes, heterocyclopentadienes: pyrrole, furan, and thiophene; synthesis of heterocyclopentadienes,.and other contents. | Cyclic molecules that contain at least 1 heteroatom Oxacyloalkane: Oxygen-containing heterocycle Azacycloalkane: Nitrogen-containing heterocycle Thiacyloalkane: Sulfur-containing heterocycle Chapter 25: Heterocycles Numbering starts at heteroatom Intramolecular SN2 reaction X : CH2− L (CH2)n 2. Special reaction for oxacyclopropanes Preparation of Heterocloalkanes Three- and four-membered rings open: ring strain Reactions Usual conditions are basic. For rings larger than four, no ring strain: Need strong acid Heterocyclopentadienes: Pyrrole, Furan, and Thiophene The lone pairs participate in the aromatic cyclic six e system: Like the cyclopentadienyl anion Pyrrole Furan Thiophene The distribution of 6 π electrons over five atoms makes these systems relatively e-rich, compared to benzene. Cyclopentadienyl anion sp2 sp2 sp2 Resonance: recall enamines Orbitals Relative to benzene: electron rich Paal-Knorr synthesis of pyrroles and its variations Synthesis of Heterocyclopentadienes 75% .

• Hoá học
• Organic chemistry
• Lecture Organic chemistry
• Hóa học hữu cơ
• Bài giảng Hóa học hữu cơ
• Oxygen containing heterocycle
• Nitrogen containing heterocycle
• In this workbook
• experiments are elaborated using small scale glassware and equipments from a Small Lab Kit
• developed at the Department of Chemistry
• Faculty of Science
• Chulalongkorn University in Thailand
• This Small Lab Kit was created as a result of the research project entitled “Chemistry Laboratory Based on Chemical Safety and Pollution Minimization” sponsored by Thai Research Fund (RDG 3 07 2543)
• One of the outcomes of this project is the organic laboratory book entitled “Organic Chemistry Laboratory Based on Chemical Safety and Pollution Minimization” written in Thai by professors from 7 universities in this project
• They compiled
• adjusted and tested the experiments taken from several traditional organic chemistry laboratory books using the prototype of Small Lab Kit
• Currently
• some selected experiments from this Thai organic chemistry laboratory text have further been modified
• rewritten and edited in English as appeared in this workbook
• Some experiments ar
• Ebook Organic chemistry
• Nucleophilic substitution
• Determining organic structures
• nucleophilic addition
• Organic structures
• Electrophilic aromatic substitution
• Principles of organic chemistry
• Methods of organic chemistry
• The methane series
• The acetylene series
• Polybasic acids
• High school
• University entrance exam
• Teaching organic chemistry
• Organic chemistry exam question
• Interdisciplinary science
• Advanced practical organic chemistry
• Functional groups
• Organic synthesis reagents
• The structure
• Reactions of organic names
• Fundamentals of organic chemistry
• Carbonyl alpha substitution reactions
• Condensation reactions
• Structure determination
• The organic chemistry
• Organic chemistry principles in context
• Starch to the principles
• The structures of organic molecules
• Mass spectrometers
• Infrared spectrometers
• Nuclear magnetic resonance spectrometers
• Modern physical organic chemistry
• Strain and stability
• Covalent binding forces
• Electronic organic materials
• Thermal pericyclic reactions
• The study of organic chemistry
• Stereochemistry and resonance
• Identification of organic compounds
• Elimination reactions
• Electrophilic addition reactions
• Electron delocalization
• Organic compounds
• Cyclic hydrocarbons
• Aromatic alcohols
• Aromatic compounds containing
• Inorganic chemistry
• A guidebook to mechanism in organic chemistry
• Aromatic systems
• Linear free energy relationships
• Symmetry controlled reactions
• Fatty acid catabolism
• The chemistry of the carbonyl group
• The industrial road toward increasing efficiency
• Chemistry of benzene
• Derivatives of benzene
• Summary of Organic Chemistry Dotoral Thesis
• Organic Chemistry Dotoral Thesis
• Natural Products Chemistry
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• Ideas in chemistry
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• Innovative processes in organic chemistry
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• Electronic Structure
• Electronic configurations of atoms
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• Alkane conformations
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• Chlorination of Methane
• Chiral carbons
• Nonmobile conformers
• Alkyl Halides