TAILIEUCHUNG - A new flavonoid Ophiopogon confertifolius
From the methanolic extract of the roots of Ophiopogon confertifolius N. Tanaka (Convallariaceae) a new flavonoid named ophiofolius A (1) and two known compounds (2, 3) were isolated. Their structures were elucidated as 6,8-dimethyl-4’methoxy-5,7,3’,5’- tetrahydroxyflavanone (1), 6,8-dimethyl-3’,4’-dimethoxy-5,7,5’-trihydroxyflavanone (2), and 6- methoxy-5,7-dihydroxyflavanone (3) by the spectroscopic evidences (1D NMR, 2D NMR, ESIMS). | Journal of Chemistry, Vol. 45 (6), P. 791 - 794, 2007 A NEW FLAVONOID FROM OPHIOPOGON CONFERTIFOLIUS Received 2 July 2007 NGUYEN THI VINH HUE , NGUYEN DUY THUAN2, NGUYEN TRONG THONG3, CHAU VAN MINH4, PHAN VAN KIEM4 1 Traphaco Joint Stock Company, Ministry of Health 1 2 National Institute of Medicinal Materials, Ministry of Health 3 Hanoi Medical University, Ministry of Health 4 Institute of Natural Products Chemistry, VAST SUMMARY From the methanolic extract of the roots of Ophiopogon confertifolius N. Tanaka (Convallariaceae) a new flavonoid named ophiofolius A (1) and two known compounds (2, 3) were isolated. Their structures were elucidated as 6,8-dimethyl-4’methoxy-5,7,3’,5’tetrahydroxyflavanone (1), 6,8-dimethyl-3’,4’-dimethoxy-5,7,5’-trihydroxyflavanone (2), and 6methoxy-5,7-dihydroxyflavanone (3) by the spectroscopic evidences (1D NMR, 2D NMR, ESIMS). I - INTRODUCTION “Cao c ng” is a traditional medicinal plant of the people who lives in some mountainous areas of Bac Giang province. It has been used to treat osteocopic pain, dispel swelling and blood clotting in ecchymosis, renal failure The scientific name of this plant has been identified as Ophiopogon confertifolius N. Tanaka (Convallariaceae). This is a new species of Vietnamese flora [1]. Up to date, no studies on the chemical and bioactivities of this plant were carried out. As a part of our study on this plant, we report herein the isolation and the structural elucidation of 8-dimethyl-4’methoxy-5,7,3’,5’tetrahydroxyflavanone (1), 6,8-dimethyl-3’,4’dimethoxy-5,7,5’-trihydroxyflavanone (2), and 6-methoxy-5,7-dihydroxyflavanone (3) by the spectroscopic evidences (1D NMR, 2D NMR, ESI-MS). Compound 1 was isolated for the first time from nature, and compounds 2 and 3 were first isolated from the Ophiopogon species. II - EXPERIMENTAL 1. Plant material The roots of Ophiopogon confertifolius N. Tanaka (Convallariaceae) were collected in Yen The, Bac Giang province, Vietnam, and the plant was .
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