TAILIEUCHUNG - Ebook Neurology and pregnancy - Clinical management: Part 2

(BQ) Part 2 book “Neurology and pregnancy - Clinical management” has contents: Infections in pregnancy, idiopathic intracranial hypertension, vascular malformations of the brain in pregnancy, pituitary disease in pregnancy, neuro-oncology in pregnancy, multiple sclerosis and pregnancy, nutritional deficiencies in pregnancy, and other contents. | 14 Infections in pregnancy Iskandar Azwa, Michael S. Marsh, and David A. Hawkins INTRODUCTION Despite the advent of antibiotics and improved diagnostic facilities, infectious diseases in pregnancy continue to contribute significantly to maternal and neonatal morbidity and mortality (1). These are most common in the developing world. About 99% of maternal deaths in the world in 2005 occurred in developing countries and 25% of maternal deaths in the developing world are due to infections in pregnancy mainly due to puerperal sepsis and septic abortion. Obstetric sepsis was the leading cause of maternal mortality in the United Kingdom until the introduction of antibiotics into clinical practice in the late 1930s. The incidence has now declined rapidly but there were still 18 direct deaths from genital tract sepsis ( of maternal deaths) reported in the 2003 to 2005 triennium in the Confidential Enquiry into Maternal Deaths (CEMD), the majority associated with beta-haemolytic streptococcus Lancefield group A and Escherichia coli infection (2). Eight out of the 18 deaths occurred during labour or before delivery. The CEMD identified risk factors for maternal sepsis which included diabetes, anaemia, history of pelvic infection, impaired immunity, history of group B streptococcal infection, amniocentesis and other invasive intrauterine procedures, cervical cerclage, prolonged spontaneous rupture of membranes, caesarean section and retained products of conception post-miscarriage or -delivery. Obesity was also identified as a risk factor for infection and led to practical difficulties in managing care. The CEMD highlighted the need to avoid complacency in maternal infection and made a number of key specific recommendations. It emphasised the importance of increased awareness by health care professionals of symptoms and signs of sepsis and septic shock and the importance of regular frequent observations if pelvic sepsis was suspected. It also stressed the importance of

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