TAILIEUCHUNG - No association between RS821616 of DISC1 gene and susceptibility to schizophrenia in a Vietnamese population

Objectives: To clarify a possible association between schizophrenia (SZ) and single nucleotide polymorphism (SNP) rs821616 within disrupted in schizophrenia 1 (DISC1) gene in a Kinh population in Vietnam. | Journal of military pharmaco-medicine No7-2017 NO ASSOCIATION BETWEEN RS821616 OF DISC1 GENE AND SUSCEPTIBILITY TO SCHIZOPHRENIA IN A VIETNAMESE POPULATION Dang Tien Truong*; Nguyen Duy Bac*; Pham Minh Dam*; Tran Hai Anh* SUMMARY Objectives: To clarify a possible association between schizophrenia (SZ) and single nucleotide polymorphism (SNP) rs821616 within disrupted in schizophrenia 1 (DISC1) gene in a Kinh population in Vietnam. Methods: We genotyped rs821616 of DISC1 gene using direct sequencing method. Results: Our case-control analysis in 201 participants (100 schizophrenic patients and 101 healthy controls of Kinh ethnicity) found no significant difference in allele frequencies and genotyping distributions between case and control groups. Conclusion: The results providing an initial evidence that SNP rs821616 has no association to susceptibility for SZ in a limited population of Kinh ethnicity in Vietnam. * Keywords: Schizophrenia; Single nucleotide polymorphism; rs821616; DISC1. INTRODUCTION Schizophrenia (SZ) is a severe mental disorder influencing multiple brain functions. The heritability is accounted about 80% in SC, with around 10-fold risk increase in first degree relatives. Genetics in SZ has long been assumed as a major component basing on family and adoption studies. Substantial evidence from genetics studies supports an important role of disrupted in schizophrenia 1 (DISC1) in regulation for neural development [6, 8], and of single nucleotide polymorphism (SNP) rs821616 (Ser704Cys) within DISC1 gene in pathophysiology of SZ [1]. Ser704Cys associated to poor concentration in SZ patients [3], frontal and temporal gray matter reduction [9], and lower hippocampal volume [2], etc. However, results on DISC1 from different populations have been inconsistent, especially between and among European and Asian populations [2, 3, 4]. Since there have still no DISC1 related data from Vietnamese people, this early study aimed to: Elucidate a possible .

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