TAILIEUCHUNG - Fabrication of curcumin loaded nano polycaprolactone chitosan nonwoven fabric via electrospinning technique
The effects of process parameter such as the applied voltage, tip–collector distance and the solution flow rate on the fiber generation and morphology of final fiber were optimized. Nanofibers morphology and structure were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), respectively. The prepared fibers had a smooth surface and fine morphology. | Journal of Science and Technology 55 (1B) (2017) 99–108 FABRICATION OF CURCUMIN LOADED NANO POLYCAPROLACTONE/CHITOSAN NONWOVEN FABRIC VIA ELECTROSPINNING TECHNIQUE Minh Son Hoang1, Ngoc Hoan Doan2, Dai Phu Huynh2, 3, * 1 Faculty of Chemical Engineering, IUH 12 Nguyen Van Bao Street, Ward 4, Go Vap District, Ho Chi Minh City, Vietnam 2 Faculty of Materials Technology, HCMUT–VNUHCM 268 Ly Thuong Kiet Street, Ward 14, District 10, Ho Chi Minh City, Vietnam 3 National Key Laboratory of Polymer and Composite Materials, HCMUT–VNUHCM 268 Ly Thuong Kiet Street, Ward 14, District 10, Ho Chi Minh City, Vietnam * Email: hdphu@ Received: 30 December 2016; Accepted for publication: 3 March 2017 ABSTRACT Cucurmin loaded poly ε–caprolactone/chitosan (PCL/CTS) nanoscale nonwoven fabric was successfully fabricated using electrospinning, a facial and efficient method. The surface tensions of PCL/CTS blend solutions in various ratios were measured to evaluate the influence of PCL/CTS ratio on fibers formation. The effects of process parameter such as the applied voltage, tip–collector distance and the solution flow rate on the fiber generation and morphology of final fiber were optimized. Nanofibers morphology and structure were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), respectively. The prepared fibers had a smooth surface and fine morphology. The diameter of fibers ranges from 200 nm to 400 nm. The release kinetics of curcumin loaded samples were also analyzed via in vitro technique. Results demonstrated that the polycaprolactone/chitosan–based nanofibers encapsulate curcumin is a potential material for wound healing acceleration. Keywords: poly ε–caprolactone, chitosan, electrospinning, wound healing. 1. INTRODUCTION Electrospinning is a technique utilizing electrostatic force to produce polymer fibers with diameters ranging from nanometers to several micrometers using the polymer solution. This is the most .
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