TAILIEUCHUNG - Ebook Pathophysiology of heart disease (5th edition): Part 2

(BQ) Part 2 book "Pathophysiology of heart disease" presents the following contents: Heart failure, the cardiomyopathies, mechanisms of cardiac arrhythmias, clinical aspects of cardiac arrhythmias, hypertension, diseases of the pericardium, diseases of the peripheral vasculature, congenital heart disease. | CHAPTER Heart Failure Neal Anjan Chatterjee Michael A. Fifer PHYSIOLOGY Determinants of Contractile Function in the Intact Heart Pressure-Volume Loops PATHOPHYSIOLOGY Heart Failure with Reduced EF Heart Failure with Preserved EF Right-Sided Heart Failure COMPENSATORY MECHANISMS Frank-Starling Mechanism Neurohormonal Alterations Ventricular Hypertrophy and Remodeling MYOCYTE LOSS AND CELLULAR DYSFuNcTION PRECIPITATING FACTORS CLINICAL MANIFESTATIONS Symptoms Physical Signs Diagnostic Studies F9 PROGNOSIS TREATMENT OF HEART FAILURE WITH REDUCED EJECTION FRACTION Diuretics Vasodilators Inotropic Drugs p-Blockers Aldosterone Antagonist Therapy Additional Therapies TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION ACUTE HEART FAILURE Acute Pulmonary Edema The heart normally accepts blood at low filling pressures during diastole and then propels it forward at higher pressures in systole. Heart failure is present when the heart is unable to pump blood forward at a sufficient rate to meet the metabolic demands of the body forward failure or is able to do so only if the cardiac filling pressures are abnormally high backward failure or both. Although conditions outside the heart may cause this definition to be met through inadequate tissue perfusion . severe hemorrhage or increased metabolic demands . hyperthyroidism in this chapter only cardiac causes of heart failure are considered. Heart failure may be the final and most severe manifestation of nearly every form of cardiac disease including coronary atherosclerosis myocardial infarction valvular diseases hypertension congenital heart disease and the cardiomyopathies. More than 500 000 new cases are diagnosed each year in the United States where the current prevalence 216 Heart Failure is approximately 5 million. The number of patients with heart failure is increasing not only because the population is aging but also because of interventions that prolong survival after damaging cardiac insults such as .

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