TAILIEUCHUNG - Lecture Organic chemistry: Chapter 17 - L. G. Wade, Jr.

Chapter 17 - Reactions of aromatic compounds. In this chapter, we will study several of these reactions and then consider how substituents on the ring influence its reactivity toward electrophilic aromatic substitution and the regiochemistry seen in the products. We will also study other reactions of aromatic compounds, including nucleophilic aromatic substitution, addition reactions, reactions of side chains, and special reactions of phenols. | Chapter 17 Copyright © 2010 Pearson Education, Inc. Organic Chemistry, 7th Edition L. G. Wade, Jr. Reactions of Aromatic Compounds Chapter 17 Electrophilic Aromatic Substitution Although benzene’s pi electrons are in a stable aromatic system, they are available to attack a strong electrophile to give a carbocation. This resonance-stabilized carbocation is called a sigma complex because the electrophile is joined to the benzene ring by a new sigma bond. Aromaticity is regained by loss of a proton. Chapter 17 Mechanism of Electrophilic Aromatic Substitution Chapter 17 Bromination of Benzene Chapter 17 Mechanism for the Bromination of Benzene: Step 1 Before the electrophilic aromatic substitution can take place, the electrophile must be activated. A strong Lewis acid catalyst, such as FeBr3, should be used. B r B r F e B r 3 B r B r F e B r 3 + - (stronger electrophile than Br2) Chapter 17 Step 2: Electrophilic attack and formation of the sigma .

• Hoá học
• Organic chemistry
• Lecture Organic chemistry
• Hóa học hữu cơ
• Electronic Structure
• Aromatic compounds
• In this workbook
• experiments are elaborated using small scale glassware and equipments from a Small Lab Kit
• developed at the Department of Chemistry
• Faculty of Science
• Chulalongkorn University in Thailand
• This Small Lab Kit was created as a result of the research project entitled “Chemistry Laboratory Based on Chemical Safety and Pollution Minimization” sponsored by Thai Research Fund (RDG 3 07 2543)
• One of the outcomes of this project is the organic laboratory book entitled “Organic Chemistry Laboratory Based on Chemical Safety and Pollution Minimization” written in Thai by professors from 7 universities in this project
• They compiled
• adjusted and tested the experiments taken from several traditional organic chemistry laboratory books using the prototype of Small Lab Kit
• Currently
• some selected experiments from this Thai organic chemistry laboratory text have further been modified
• rewritten and edited in English as appeared in this workbook
• Some experiments ar
• Ebook Organic chemistry
• Nucleophilic substitution
• Determining organic structures
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• Electrophilic aromatic substitution
• Principles of organic chemistry
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