TAILIEUCHUNG - Lecture Genetics: From genes to genomes - Chapter 6: DNA structure, replication, and recombination
Chapter 6 - DNA structure, replication, and recombination. This chapter includes contents: Experimental evidence for DNA as the genetic material, the Watson and Crick double helix model of DNA, genetic information in DNA base sequence, DNA replication, recombination at the DNA level. | Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display PowerPoint to accompany Genetics: From Genes to Genomes Fourth Edition Leland H. Hartwell, Leroy Hood, Michael L. Goldberg, Ann E. Reynolds, and Lee M. Silver Prepared by Mary A. Bedell University of Georgia Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th ed., Chapter 6 CHAPTER What Genes Are and What They Do CHAPTER PART II CHAPTER OUTLINE DNA Structure, Replication, and Recombination Experimental Evidence for DNA as the Genetic Material The Watson and Crick Double Helix Model of DNA Genetic Information in DNA Base Sequence DNA Replication Recombination at the DNA Level Two general themes to genes at the molecular levels The genetic functions of DNA flow directly from its molecular structure Knowledge of molecular structure of DNA makes it possible to understand biochemical processes of genetics All of the genetics functions of DNA depend on specialized proteins that "read" the information in DNA sequence DNA itself is chemically inert Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th ed., Chapter 6 Chemical studies located DNA in the chromosomes F. Meischer (1869) extracted "nuclein" from nuclei of human white blood cells Weakly acidic, phosphorus rich material Chemical analysis of nuclein revealed that its major component was deoxyribonucleic acid (DNA) Contains deoxyribose, found in nucleus, and is acidic Staining of cells revealed that DNA localized almost exclusively within chromosomes Schiff reagent – stains DNA red Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th ed., Chapter 6 The chemical composition of DNA DNA contains four kinds of nucleotides linked in a long chain Phosphodiester bonds – covalent bonds joining adjacent nucleotides Polymer – .
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